| Item type |
Thesis or Dissertation(1) |
| 公開日 |
2022-11-10 |
| タイトル |
|
|
タイトル |
Functional Role of HSP47 in the Periodontal Ligament Subjected to Occlusal Overload in Mice |
|
言語 |
en |
| その他(別言語等)のタイトル |
|
|
その他のタイトル |
マウス歯根膜における咬合過重負荷時のHSP47 の機能的役割 |
| 作成者(その他言語) |
Mimura, Hiroaki
Takaya, Tatsuo
Matsuda, Saeka
Nakano, Keisuke
Muraoka, Rina
Tomida, Mihoko
Okafuji, Norimasa
Fujii, Takeo
Kawakami, Toshiyuki
三村, 泰亮
|
| 書誌情報 |
International Journal of Medical Sciences
巻 13,
号 4,
p. 248-254,
発行日 2016-02-20
|
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Occlusal trauma |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Periodontal ligament |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Immunohistochemistry |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
HSP47 |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Mouse |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_db06 |
|
資源タイプ |
doctoral thesis |
| アクセス権 |
|
|
アクセス権 |
metadata only access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_14cb |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
We carried out an experiment to induce traumatic occlusion in mice periodontal tissue and analyzed the expression of HSP47. Continuous traumatic occlusion resulted to damage and remodeling of periodontal ligament as well as increase in osteoclasts and bone resorption. Four days after traumatic occlusion, osteoclasts did not increase but Howship’s lacunae became enlarged. That is, the persistent occlusal overload can destroy collagen fibers in the periodontal ligament. This was evident by the increased in HSP47 expression with the occlusal overload. HSP47 is maintained in fibroblasts for repair of damaged collagen fibers. On the other hand, osteoclasts continue to increase although the load was released. The osteoclasts that appeared on the alveolar bone surface were likely due to sustained activity. The increase in osteoclasts was estimated to occur after load application at day 4. HSP47 continued to increase until day 6 in experiment 2 but then reduced at day 10. Therefore, HSP47 appears after a period of certain activities to repair damaged collagen fibers, and the activity was returned to a state of equilibrium at day 30 with significantly diminished expression. Thus, the results suggest that HSP47 is actively involved in homeostasis of periodontal tissue subjected to occlusal overload. |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
2016 |
| 日付 |
|
|
日付 |
2017-04-27 |
|
日付タイプ |
Created |
| フォーマット |
|
|
内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
| その他の資源識別子 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
甲第203号 |
| 資源識別子URI |
|
|
識別子 |
http://id.nii.ac.jp/1070/00002656/ |
|
識別子タイプ |
URI |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1449-1907 |
| 情報源 |
|
|
|
関連名称 |
雑誌掲載論文(電子版) |
| 情報源 |
|
|
|
関連名称 |
http://www.medsci.org/v13p0248.htm |
| PubMed番号 |
|
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
info:pmid/27076780 |
| DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.7150/ijms.14129 |
| 権利 |
|
|
権利情報 |
Copyright: 2016 © Ivyspring International Publisher. This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See http://ivyspring.com/terms for full terms and conditions. |
| 権利 |
|
|
権利情報 |
CC BY-NC |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 学位授与番号 |
|
|
学位授与番号 |
甲第203号 |
| 学位授与年月日 |
|
|
学位授与年月日 |
2017-02-09 |
| 学位名 |
|
|
学位名 |
博士（歯学） |
| 学位授与機関 |
|
|
|
学位授与機関名 |
松本歯科大学 |
