{"created":"2023-05-15T16:11:30.306181+00:00","id":41884,"links":{},"metadata":{"_buckets":{"deposit":"124380e5-00da-43df-ad00-72d004623637"},"_deposit":{"created_by":25,"id":"41884","owners":[25],"pid":{"revision_id":0,"type":"depid","value":"41884"},"status":"published"},"_oai":{"id":"oai:shinshu.repo.nii.ac.jp:00041884","sets":[]},"author_link":["164189","164187","164191","164193","164190","164192","164188","164194","164185","164186"],"item_20003_alternative_title_1":{"attribute_name":"その他(別言語等)のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"マウス歯根膜における咬合過重負荷時のHSP47 の機能的役割"}]},"item_20003_biblio_info_27":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-02-20","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"254","bibliographicPageStart":"248","bibliographicVolumeNumber":"13","bibliographic_titles":[{"bibliographic_title":"International Journal of Medical Sciences"}]}]},"item_20003_creator_3":{"attribute_name":"作成者(その他言語)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Mimura, Hiroaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takaya, Tatsuo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsuda, Saeka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakano, Keisuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Muraoka, Rina"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tomida, Mihoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okafuji, Norimasa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fujii, Takeo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawakami, Toshiyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"三村, 泰亮"}],"nameIdentifiers":[{}]}]},"item_20003_date_19":{"attribute_name":"日付","attribute_value_mlt":[{"subitem_date_issued_datetime":"2017-04-27","subitem_date_issued_type":"Created"}]},"item_20003_date_granted_56":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2017-02-09"}]},"item_20003_degree_grantor_58":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"松本歯科大学"}],"subitem_degreegrantor_identifier":[{}]}]},"item_20003_degree_name_57":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）"}]},"item_20003_description_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"We carried out an experiment to induce traumatic occlusion in mice periodontal tissue and analyzed the expression of HSP47. Continuous traumatic occlusion resulted to damage and remodeling of periodontal ligament as well as increase in osteoclasts and bone resorption. Four days after traumatic occlusion, osteoclasts did not increase but Howship’s lacunae became enlarged. That is, the persistent occlusal overload can destroy collagen fibers in the periodontal ligament. This was evident by the increased in HSP47 expression with the occlusal overload. HSP47 is maintained in fibroblasts for repair of damaged collagen fibers. On the other hand, osteoclasts continue to increase although the load was released. The osteoclasts that appeared on the alveolar bone surface were likely due to sustained activity. The increase in osteoclasts was estimated to occur after load application at day 4. HSP47 continued to increase until day 6 in experiment 2 but then reduced at day 10. Therefore, HSP47 appears after a period of certain activities to repair damaged collagen fibers, and the activity was returned to a state of equilibrium at day 30 with significantly diminished expression. Thus, the results suggest that HSP47 is actively involved in  homeostasis of periodontal tissue subjected to occlusal overload.","subitem_description_type":"Other"},{"subitem_description":"2016","subitem_description_type":"Other"}]},"item_20003_description_21":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_20003_description_22":{"attribute_name":"その他の資源識別子","attribute_value_mlt":[{"subitem_description":"甲第203号","subitem_description_type":"Other"}]},"item_20003_dissertation_number_55":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第203号"}]},"item_20003_identifier_23":{"attribute_name":"資源識別子URI","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"http://id.nii.ac.jp/1070/00002656/"}]},"item_20003_relation_28":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"雑誌掲載論文(電子版)"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"http://www.medsci.org/v13p0248.htm"}]}]},"item_20003_relation_31":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"info:pmid/27076780","subitem_relation_type_select":"PMID"}}]},"item_20003_relation_32":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.7150/ijms.14129","subitem_relation_type_select":"DOI"}}]},"item_20003_rights_50":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright: 2016 © Ivyspring International Publisher. This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See http://ivyspring.com/terms for full terms and conditions."},{"subitem_rights":"CC BY-NC"}]},"item_20003_source_id_25":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1449-1907","subitem_source_identifier_type":"ISSN"}]},"item_20003_version_type_51":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"url":{"url":"https://mdu.repo.nii.ac.jp/?action=repository_action_common_download&item_id=2665&item_no=1&attribute_id=20&file_no=2"}},{"url":{"url":"https://mdu.repo.nii.ac.jp/?action=repository_action_common_download&item_id=2665&item_no=1&attribute_id=20&file_no=1"}}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Occlusal trauma","subitem_subject_scheme":"Other"},{"subitem_subject":"Periodontal ligament","subitem_subject_scheme":"Other"},{"subitem_subject":"Immunohistochemistry","subitem_subject_scheme":"Other"},{"subitem_subject":"HSP47","subitem_subject_scheme":"Other"},{"subitem_subject":"Mouse","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Functional Role of HSP47 in the Periodontal Ligament Subjected to Occlusal Overload in Mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Functional Role of HSP47 in the Periodontal Ligament Subjected to Occlusal Overload in Mice","subitem_title_language":"en"}]},"item_type_id":"20003","owner":"25","path":["2774"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-11-10"},"publish_date":"2022-11-10","publish_status":"0","recid":"41884","relation_version_is_last":true,"title":["Functional Role of HSP47 in the Periodontal Ligament Subjected to Occlusal Overload in Mice"],"weko_creator_id":"25","weko_shared_id":25},"updated":"2023-05-15T18:01:00.328850+00:00"}