| Item type |
Journal Article(1) |
| 公開日 |
2021-04-01 |
| タイトル |
|
|
タイトル |
Notch signaling acts on cell differentiation and acquisition of tumor-specific character of oral neoplasms |
|
言語 |
en |
| 作成者(その他言語) |
Keisuke, Nakano
Kiyofumi, Takabatake
Hotaka, Kawai
Saori, Yoshida
Hatsuhiko, Maeda
Toshiyuki, Kawakami
Hitoshi, Nagatsuka 1
|
| 公開者(その他言語) |
|
|
|
姓名 |
MDPI, AG |
| 書誌情報 |
International Journal of Molecular Sciences
巻 20,
号 8,
p. 1973,
発行日 2019
|
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
odontogenic tumor |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
pleomorphic adenoma |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
notch signaling |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
cell differentiation |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
immunohistochemistry |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
epithelial-mesenchymal interaction |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
malignant transformation |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
metadata only access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_14cb |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Histopathological findings of oral neoplasm cell differentiation and metaplasia suggest that tumor cells induce their own dedifferentiation and re-differentiation and may lead to the formation of tumor-specific histological features. Notch signaling is involved in the maintenance of tissue stem cell nature and regulation of differentiation and is responsible for the cytological regulation of cell fate, morphogenesis, and/or development. In our previous study, immunohistochemistry was used to examine Notch expression using cases of odontogenic tumors and pleomorphic adenoma as oral neoplasms. According to our results, Notch signaling was specifically associated with tumor cell differentiation and metaplastic cells of developmental tissues. Notch signaling was involved in the differentiation of the ductal epithelial cells of salivary gland tumors and ameloblast-like cells of odontogenic tumors. However, Notch signaling was also involved in squamous metaplasia, irrespective of the type of developmental tissue. In odontogenic tumors, Notch signaling was involved in epithelial–mesenchymal interactions and may be related to tumor development and tumorigenesis. This signaling may also be associated with the malignant transformation of ameloblastomas. Overall, Notch signaling appears to play a major role in the formation of the characteristic cellular composition and histological features of oral neoplasms, and this involvement has been reviewed here. |
| 日付 |
|
|
日付 |
2019-04-25 |
|
日付タイプ |
Created |
| フォーマット |
|
|
内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
| 資源識別子URI |
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|
識別子 |
http://id.nii.ac.jp/1070/00002818/ |
|
識別子タイプ |
URI |
| ISSN |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1422-0067 |
| 情報源 |
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|
関連名称 |
https://doi.org/10.3390/ijms20081973 |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.3390/ijms20081973 |
| 権利 |
|
|
権利情報 |
© by the authors. Licensee MDPI, Basel, Switzerland. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0). (http://creativecommons.org/licenses/by/4.0]/) |
| 権利 |
|
|
権利情報 |
CC BY |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
https://mdu.repo.nii.ac.jp/?action=repository_action_common_download&item_id=2828&item_no=1&attribute_id=22&file_no=1
