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  1. 松本歯科大学
  2. 学術雑誌論文
  3. International Journal of Molecular Sciences
  1. 松本歯科大学
  2. 成果物登録者(学内著者)一覧
  3. K
  4. Toshiyuki Kawakami

Notch signaling acts on cell differentiation and acquisition of tumor-specific character of oral neoplasms

https://shinshu.repo.nii.ac.jp/records/44428
https://shinshu.repo.nii.ac.jp/records/44428
6de27232-cac6-4e86-81c6-f6d8a0bd2dcf
名前 / ファイル ライセンス アクション
/ https://mdu.repo.nii.ac.jp/?action=repository_action_common_download&item_id=2828&item_no=1&attribute_id=22&file_no=1
Item type Journal Article(1)
公開日 2021-04-01
タイトル
タイトル Notch signaling acts on cell differentiation and acquisition of tumor-specific character of oral neoplasms
言語 en
作成者(その他言語) Keisuke, Nakano

× Keisuke, Nakano

Keisuke, Nakano

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Kiyofumi, Takabatake

× Kiyofumi, Takabatake

Kiyofumi, Takabatake

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Hotaka, Kawai

× Hotaka, Kawai

Hotaka, Kawai

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Saori, Yoshida

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Saori, Yoshida

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Hatsuhiko, Maeda

× Hatsuhiko, Maeda

Hatsuhiko, Maeda

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Toshiyuki, Kawakami

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Toshiyuki, Kawakami

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Hitoshi, Nagatsuka 1

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Hitoshi, Nagatsuka 1

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公開者(その他言語)
姓名 MDPI, AG
書誌情報 International Journal of Molecular Sciences

巻 20, 号 8, p. 1973, 発行日 2019
言語
言語 eng
キーワード
主題Scheme Other
主題 odontogenic tumor
キーワード
主題Scheme Other
主題 pleomorphic adenoma
キーワード
主題Scheme Other
主題 notch signaling
キーワード
主題Scheme Other
主題 cell differentiation
キーワード
主題Scheme Other
主題 immunohistochemistry
キーワード
主題Scheme Other
主題 epithelial-mesenchymal interaction
キーワード
主題Scheme Other
主題 malignant transformation
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
内容記述
内容記述タイプ Other
内容記述 Histopathological findings of oral neoplasm cell differentiation and metaplasia suggest that tumor cells induce their own dedifferentiation and re-differentiation and may lead to the formation of tumor-specific histological features. Notch signaling is involved in the maintenance of tissue stem cell nature and regulation of differentiation and is responsible for the cytological regulation of cell fate, morphogenesis, and/or development. In our previous study, immunohistochemistry was used to examine Notch expression using cases of odontogenic tumors and pleomorphic adenoma as oral neoplasms. According to our results, Notch signaling was specifically associated with tumor cell differentiation and metaplastic cells of developmental tissues. Notch signaling was involved in the differentiation of the ductal epithelial cells of salivary gland tumors and ameloblast-like cells of odontogenic tumors. However, Notch signaling was also involved in squamous metaplasia, irrespective of the type of developmental tissue. In odontogenic tumors, Notch signaling was involved in epithelial–mesenchymal interactions and may be related to tumor development and tumorigenesis. This signaling may also be associated with the malignant transformation of ameloblastomas. Overall, Notch signaling appears to play a major role in the formation of the characteristic cellular composition and histological features of oral neoplasms, and this involvement has been reviewed here.
日付
日付 2019-04-25
日付タイプ Created
フォーマット
内容記述タイプ Other
内容記述 application/pdf
資源識別子URI
識別子 http://id.nii.ac.jp/1070/00002818/
識別子タイプ URI
ISSN
収録物識別子タイプ ISSN
収録物識別子 1422-0067
情報源
関連名称 https://doi.org/10.3390/ijms20081973
DOI
関連タイプ isIdenticalTo
識別子タイプ DOI
関連識別子 https://doi.org/10.3390/ijms20081973
権利
権利情報 © by the authors. Licensee MDPI, Basel, Switzerland. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0). (http://creativecommons.org/licenses/by/4.0]/)
権利
権利情報 CC BY
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
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