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アイテム
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As the Wisteria floribunda agglutinin-positive Mac-2-binding protein (WFA+-M2BP) was recently established as a liver fibrosis glycobiomarker in chronic hepatitis C, we assessed its efficacy in evaluating liver fibrosis stage and disease progression in PBC.METHODS:A total of 137 patients with PBC who underwent liver biopsy and serological tests for WFA+-M2BP were enrolled. All patients were treated with ursodeoxycholic acid. Clinical data were compared with those for other noninvasive markers (aspartate aminotransferase-to-platelet ratio, FIB-4 index, aspartate aminotransferase/alanine aminotransferase ratio, Forn’s index, and Mayo score) for estimating liver fibrosis using receiver operating characteristic analysis. 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Serum Wisteria floribunda Agglutinin-Positive Mac-2-Binding Protein Level Predicts Liver Fibrosis and Prognosis in Primary Biliary Cirrhosis
https://shinshu.repo.nii.ac.jp/records/43840
https://shinshu.repo.nii.ac.jp/records/4384027a64586-cb71-45e9-818e-57617d7cd7f2
名前 / ファイル | ライセンス | アクション |
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https://soar-ir.repo.nii.ac.jp/?action=repository_action_common_download&item_id=20239&item_no=1&attribute_id=65&file_no=1
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Item type | Journal Article(1) | |||||
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公開日 | 2020-09-04 | |||||
タイトル | ||||||
タイトル | Serum Wisteria floribunda Agglutinin-Positive Mac-2-Binding Protein Level Predicts Liver Fibrosis and Prognosis in Primary Biliary Cirrhosis | |||||
作成者(その他言語) |
Umemura, Takeji
× Umemura, Takeji× Joshita, Satoru× Sekiguchi, Tomohiro× Usami, Yoko× Shibata, Soichiro× Kimura, Takefumi× Komatsu, Michiharu× Matsumoto, Akihiro× Ota, Masao× Tanaka, Eiji |
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公開者(その他言語) | ||||||
姓名 | NATURE, PUBLISHING GROUP | |||||
書誌情報 |
AMERICAN JOURNAL OF GASTROENTEROLOGY 巻 110, 号 6, p. 857-864, 発行日 2015-04-28 |
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言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Autoimmune Liver Disease | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Glycoprotein | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Biomarker | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | OBJECTIVES:Noninvasive markers of liver fibrosis in patients with primary biliary cirrhosis (PBC) are needed for predicting disease progression. As the Wisteria floribunda agglutinin-positive Mac-2-binding protein (WFA+-M2BP) was recently established as a liver fibrosis glycobiomarker in chronic hepatitis C, we assessed its efficacy in evaluating liver fibrosis stage and disease progression in PBC.METHODS:A total of 137 patients with PBC who underwent liver biopsy and serological tests for WFA+-M2BP were enrolled. All patients were treated with ursodeoxycholic acid. Clinical data were compared with those for other noninvasive markers (aspartate aminotransferase-to-platelet ratio, FIB-4 index, aspartate aminotransferase/alanine aminotransferase ratio, Forn’s index, and Mayo score) for estimating liver fibrosis using receiver operating characteristic analysis. The association between WFA+-M2BP and clinical outcome (liver decompensation, liver transplantation, or death) was evaluated using the Cox proportional hazards model with stepwise method.RESULTS:WFA+-M2BP was independently associated with liver fibrosis stage as determined by liver biopsy. The cutoff values of WFA+-M2BP for fibrosis stages ≥F1, ≥F2, ≥F3, and F4 were 0.7, 1.0, 1.4, and 2.0, respectively. The area under the receiver operating characteristic curve values for significant fibrosis, severe fibrosis, and cirrhosis were 0.979, 0.933, and 0.965, respectively. WFA+-M2BP was significantly superior to the other indices for the determination of significant and severe fibrosis stages. Furthermore, the WFA+-M2BP level at enrollment was strongly and independently associated with clinical outcome (hazard ratio 18.59, P=0.021).CONCLUSIONS:Baseline measurements of WFA+-M2BP represent a simple and reliable noninvasive surrogate marker of liver fibrosis and prognosis in patients with PBC. | |||||
日付 | ||||||
日付 | 2018-11-01 | |||||
日付タイプ | Created | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
その他の資源識別子 | ||||||
内容記述タイプ | Other | |||||
内容記述 | AMERICAN JOURNAL OF GASTROENTEROLOGY.110(6):857-864(2015) | |||||
資源識別子URI | ||||||
識別子 | http://hdl.handle.net/10091/00020997 | |||||
識別子タイプ | HDL | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0002-9270 | |||||
処理レコードID(総合目録DB) | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00520662 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | https://www.ncbi.nlm.nih.gov/pubmed/25916223 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1038/ajg.2015.118 | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa |