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Smoking influences the yield of dendritic cells for cancer immunotherapy
https://shinshu.repo.nii.ac.jp/records/42422
https://shinshu.repo.nii.ac.jp/records/424225f3f2866-37c0-40f0-adff-4396b531fdfb
名前 / ファイル | ライセンス | アクション |
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https://soar-ir.repo.nii.ac.jp/?action=repository_action_common_download&item_id=19350&item_no=1&attribute_id=65&file_no=1
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Item type | Journal Article(1) | |||||
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公開日 | 2020-09-04 | |||||
タイトル | ||||||
タイトル | Smoking influences the yield of dendritic cells for cancer immunotherapy | |||||
作成者(その他言語) |
Shimodaira, S
× Shimodaira, S× Higuchi, Y× Koya, T× Kobayashi, T× Yanagisawa, R× Hirabayashi, K× Ito, K× Koizumi, T× Maejima, S× Udagawa, N |
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公開者(その他言語) | ||||||
姓名 | OMICS, International | |||||
書誌情報 |
Pharmaceutical Regulatory Affairs 巻 4, 号 1, p. 133, 発行日 2015-02-09 |
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言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | DC vaccination | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Smoking | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cancer immunotherapy | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Background: Dendritic cell (DC)-based vaccination is considered to be a potentially effective therapeutic strategy against advanced cancer. The aim of this study was to address the smoking history that might affect the preparation of DC vaccines in validated instructional manufacture. Materials and Methods: Data on mature DCs generated from 102 sessions of leukapheresis performed on 92 patients with advanced cancer or sarcoma were retrospectively evaluated and compared in relation to the data between their smoking history and the generation of DCs from these patients. 61 patients with adenocarcinoma, including 7 with lung, 10 with breast, 8 with stomach, 12 with colorectal, and 23 with pancreatic adenocarcinoma were enrolled. Results: The average yield of autologous DCs (15.5 ± 8.3x107) was thought to be dependent on the number of monocytes (124.2 ± 74.1x107) collected by leukapheresis. The average ratio of DCs/apheresed monocytes (DC/aM ratio) was lower in the smoker group (11.1 ± 7.2%) than that in the non-smoker group (17.2 ± 9.3%, p=0.001). The number of DCs and the DC/aM ratio were lower in the patients with gastric and pancreatic cancer than in those with adenocarcinoma of other sites. Conclusions: As cancer therapy moves forward into the field of persona | |||||
日付 | ||||||
日付 | 2017-12-28 | |||||
日付タイプ | Created | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
その他の資源識別子 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Pharmaceutical Regulatory Affairs. 4(1):133 (2015) | |||||
資源識別子URI | ||||||
識別子 | http://hdl.handle.net/10091/00020111 | |||||
識別子タイプ | HDL | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2167-7689 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | http://doi.org/10.4172/2167-7689.1000133 | |||||
権利 | ||||||
権利情報 | © 2015 Shimodaira S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |||||
権利 | ||||||
権利情報 | © 2015 Shimodaira S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |