{"created":"2023-05-15T16:13:53.310017+00:00","id":44426,"links":{},"metadata":{"_buckets":{"deposit":"75494781-0e2c-4e4d-97da-220cbe31272f"},"_deposit":{"created_by":25,"id":"44426","owners":[25],"pid":{"revision_id":0,"type":"depid","value":"44426"},"status":"published"},"_oai":{"id":"oai:shinshu.repo.nii.ac.jp:00044426","sets":[]},"author_link":["172487","172489","172488","172490","172486","172485"],"item_20002_biblio_info_27":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-11-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicPageEnd":"482","bibliographicPageStart":"475-482","bibliographicVolumeNumber":"15","bibliographic_titles":[{"bibliographic_title":"European journal of medical research"}]}]},"item_20002_creator_3":{"attribute_name":"作成者(その他言語)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Muraoka, R"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakano, K"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kurihara, S"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamada, K"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawakami, T"}],"nameIdentifiers":[{}]}]},"item_20002_date_19":{"attribute_name":"日付","attribute_value_mlt":[{"subitem_date_issued_datetime":"2019-04-25","subitem_date_issued_type":"Created"}]},"item_20002_description_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"The histopathology of periodontal ligament of the mouse subjected to mechanical stress was studied. Immunohistochemical expressions of HSP27 and p-HSP27 were examined. Experimental animals using the maxillary molars of ddY mouse by Waldo method were used in the study. A separator was inserted to induce mechanical stress. After 10 minutes, 20 minutes, 1 hour, 3 hours, 9 hours and 24 hours, the regional tissues were extracted, fixed in 4% paraformaldehyde and 0.05M phosphate-buffered fixative solution. Paraffin sections were made for immunohistochemistry using HSP27 and p-HSP27. In the control group, the periodontal ligament fibroblasts expressed low HSP27 and p-HSP27. However, in the experimental group, periodontal ligament fibroblasts expressed HSP27 10 minutes after mechanical load application in the tension side. The strongest expression was detected 9 hours after inducing mechanical load. p-HSP27 was also expressed in a time-dependent manner though weaker than HSP27. The findings suggest that HSP27 and p- HSP27 were expressed for the maintenance of homeostasis of periodontal ligament by the activation of periodontal ligament fibroblasts on the tension side. It also suggests that these proteins act as molecular chaperones for osteoblast activation and maintenance of homeostasis.","subitem_description_type":"Other"}]},"item_20002_description_21":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_20002_full_name_16":{"attribute_name":"公開者(その他言語)","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"I., Holzapfel(BioMed Central)"}]}]},"item_20002_identifier_23":{"attribute_name":"資源識別子URI","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"http://id.nii.ac.jp/1070/00002816/"}]},"item_20002_relation_28":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"博士学位論文(2010年度松本歯科大学大学院歯学独立研究科)"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"https://doi.org/10.1186/2047-783X-15-11-475"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3352656/"}]}]},"item_20002_relation_31":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:pmid/21159572","subitem_relation_type_select":"PMID"}}]},"item_20002_relation_32":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1186/2047-783X-15-11-475","subitem_relation_type_select":"DOI"}}]},"item_20002_rights_50":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"©  I. Holzapfel Publishers 2010. licensed under the Creative Commons Attribution License 4.0. (https://creativecommons.org/licenses/by/4.0/legalcode)"},{"subitem_rights":"CC BY"}]},"item_20002_source_id_25":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2047-783x","subitem_source_identifier_type":"ISSN"}]},"item_20002_source_id_26":{"attribute_name":"処理レコードID(総合目録DB)","attribute_value_mlt":[{"subitem_source_identifier":"AA11331989","subitem_source_identifier_type":"NCID"}]},"item_20002_version_type_51":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"url":{"url":"https://mdu.repo.nii.ac.jp/?action=repository_action_common_download&item_id=2826&item_no=1&attribute_id=22&file_no=1"}}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Heat schock protein","subitem_subject_scheme":"Other"},{"subitem_subject":"HSP27","subitem_subject_scheme":"Other"},{"subitem_subject":"periodontal ligament calls","subitem_subject_scheme":"Other"},{"subitem_subject":"mechanical stress","subitem_subject_scheme":"Other"},{"subitem_subject":"orthodontic tooth movement","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Immunohistochemical expression of heat shock proteins in the mouse periodontal tissues due to orthodontic mechanical stress.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Immunohistochemical expression of heat shock proteins in the mouse periodontal tissues due to orthodontic mechanical stress.","subitem_title_language":"en"}]},"item_type_id":"20002","owner":"25","path":["2517","2521","2657","2718","2919"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-04-01"},"publish_date":"2021-04-01","publish_status":"0","recid":"44426","relation_version_is_last":true,"title":["Immunohistochemical expression of heat shock proteins in the mouse periodontal tissues due to orthodontic mechanical stress."],"weko_creator_id":"25","weko_shared_id":-1},"updated":"2023-05-15T17:52:11.304757+00:00"}