{"created":"2023-05-15T16:13:12.359864+00:00","id":43738,"links":{},"metadata":{"_buckets":{"deposit":"324328b1-4662-466f-b2cf-561be33ca40a"},"_deposit":{"created_by":25,"id":"43738","owners":[25],"pid":{"revision_id":0,"type":"depid","value":"43738"},"status":"published"},"_oai":{"id":"oai:shinshu.repo.nii.ac.jp:00043738","sets":["2668"]},"author_link":["169793","169783","169790","169786","169782","169784","169785","169787","169795","169788","169792","169794","169789","169791"],"item_20002_biblio_info_27":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-02-24","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageStart":"e0172601","bibliographicVolumeNumber":"12","bibliographic_titles":[{"bibliographic_title":"PLOS ONE"}]}]},"item_20002_creator_3":{"attribute_name":"作成者(その他言語)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tanaka, Manabu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sato, Yoshinori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Haniu, Hisao"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nomura, Hiroki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kobayashi, Shinsuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takanashi, Seiji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okamoto, Masanori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takizawa, Takashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Aoki, Kaoru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Usui, Yuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Oishi, Ayumu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kato, Hiroyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Saito, Naoto"}],"nameIdentifiers":[{}]}]},"item_20002_date_19":{"attribute_name":"日付","attribute_value_mlt":[{"subitem_date_issued_datetime":"2018-10-31","subitem_date_issued_type":"Created"}]},"item_20002_description_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Many recent studies have been conducted to assess the ability of composite materials containing carbon nanotubes (CNTs) with high bone affinity to serve as scaffolds in bone regenerative medicine. These studies have demonstrated that CNTs can effectively induce bone formation. However, no studies have investigated the usefulness of scaffolds consisting exclusively of CNTs in bone regenerative medicine. We built a three-dimensional block entity with maximized mechanical strength from multi-walled CNTs (MWCNT blocks) and evaluated their efficacy as scaffold material for bone repair. When MWCNT blocks containing recombinant human bone morphogenetic protein-2 (rhBMP-2) were implanted in mouse muscle, ectopic bone was formed in direct contact with the blocks. Their bone marrow densities were comparable to those of PET-reinforced collagen sheets with rhBMP-2. On day 1 and day 3, MC3T3-E1 preosteoblasts were attached to the scaffold surface of MWCNT blocks than that of PET-reinforced collagen sheets. They also showed a maximum compression strength comparable to that of cortical bone. Our MWCNT blocks are expected to serve as bone defect filler and scaffold material for bone regeneration.","subitem_description_type":"Other"}]},"item_20002_description_20":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_20002_description_22":{"attribute_name":"その他の資源識別子","attribute_value_mlt":[{"subitem_description":"PLOS ONE.12(2):e0172601(2017)","subitem_description_type":"Other"}]},"item_20002_full_name_16":{"attribute_name":"公開者(その他言語)","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"PUBLIC, LIBRARY SCIENCE"}]}]},"item_20002_identifier_23":{"attribute_name":"資源識別子URI","attribute_value_mlt":[{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/10091/00020975"}]},"item_20002_relation_31":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.ncbi.nlm.nih.gov/pubmed/28235026","subitem_relation_type_select":"PMID"}}]},"item_20002_relation_32":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1371/journal.pone.0172601","subitem_relation_type_select":"DOI"}}]},"item_20002_rights_50":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2017 Tanaka et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited"},{"subitem_rights":"© 2017 Tanaka et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited"}]},"item_20002_source_id_25":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1932-6203","subitem_source_identifier_type":"ISSN"}]},"item_20002_version_type_51":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"url":{"url":"https://soar-ir.repo.nii.ac.jp/?action=repository_action_common_download&item_id=20217&item_no=1&attribute_id=65&file_no=1"}}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"A three-dimensional block structure consisting exclusively of carbon nanotubes serving as bone regeneration scaffold and as bone defect filler","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A three-dimensional block structure consisting exclusively of carbon nanotubes serving as bone regeneration scaffold and as bone defect filler"}]},"item_type_id":"20002","owner":"25","path":["2668"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-03-01"},"publish_date":"2021-03-01","publish_status":"0","recid":"43738","relation_version_is_last":true,"title":["A three-dimensional block structure consisting exclusively of carbon nanotubes serving as bone regeneration scaffold and as bone defect filler"],"weko_creator_id":"25","weko_shared_id":-1},"updated":"2023-05-15T17:56:02.977080+00:00"}