{"created":"2023-05-15T16:12:14.418838+00:00","id":42669,"links":{},"metadata":{"_buckets":{"deposit":"6b805aad-877a-44ba-bb3b-d6906253ece5"},"_deposit":{"created_by":25,"id":"42669","owners":[25],"pid":{"revision_id":0,"type":"depid","value":"42669"},"status":"published"},"_oai":{"id":"oai:shinshu.repo.nii.ac.jp:00042669","sets":[]},"author_link":["166502","166501","166495","166499","166500","166496","166497","166498"],"item_20002_biblio_info_27":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-01-18","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1:1000162","bibliographicVolumeNumber":"7","bibliographic_titles":[{"bibliographic_title":"Journal of Tissue Science & Engineering"}]}]},"item_20002_creator_3":{"attribute_name":"作成者(その他言語)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"YAGAMI, KIMITOSHI"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SADAOKA, SUNAO"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"NAKAMURA, HIROSHI"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KOMATSU, SAHO"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"ONODERA, JUN"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SUZUKI, MASAHIKO"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KUBOKI, YOSHINORI"}],"nameIdentifiers":[{}]}]},"item_20002_date_19":{"attribute_name":"日付","attribute_value_mlt":[{"subitem_date_issued_datetime":"2018-03-02","subitem_date_issued_type":"Created"}]},"item_20002_description_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"In order to establish the convertibility of a host for bone augmentation, we herein developed a new honeycombshaped β-tricalcium phosphate (37H) using atelocollagen as a scaffold, which exhibited unique geometric properties for in vitro and in vivo studies.Human mesenchymal stem cells (MSC) were cultured with 37H or atelocollagen-coated honeycomb-shaped β-tricalcium phosphate (Col37H), and their osteoblastic differentiation was then analyzed. Atelocollagen promoted cell adhesion and formation of vessel-like structures in the tunnels of scaffolds of cultured MSC. The mRNA expression levels of type I collagen, osteocalcin, and VEGF were greater in MSC cultured with Col37H than with 37H. Bone generation with Col37H in the rat calvaria was greater than with 37H, and this was attributed to early vessel construction. A large number of blood vessels invaded tunnels from the periosteum and existing bone surface. A strong VEGF signal was detected immediately before the new bone surface in the tunnels of Col37H. These   results indicate that the addition of atelocollagen to Col37H has potential in the construction of functional artificial bone.","subitem_description_type":"Other"}]},"item_20002_description_21":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_20002_full_name_16":{"attribute_name":"公開者(その他言語)","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"OMICS, International"}]}]},"item_20002_identifier_23":{"attribute_name":"資源識別子URI","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"http://id.nii.ac.jp/1070/00002681/"}]},"item_20002_relation_28":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"雑誌掲載論文(電子版)"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"https://www.omicsonline.org/open-access/atelocollagen-enhanced-osteogenesis-in-a-geometric-structured-betatcpscaffold-by-vegf-induction-2157-7552-1000162.php?aid=68248"}]}]},"item_20002_relation_32":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.4172/2157-7552.1000162","subitem_relation_type_select":"DOI"}}]},"item_20002_rights_50":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright: © 2016 Yagami K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.(https://creativecommons.org/licenses/by/4.0/)"},{"subitem_rights":"CC BY"}]},"item_20002_source_id_25":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2157-7552","subitem_source_identifier_type":"ISSN"}]},"item_20002_version_type_51":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"url":{"url":"https://mdu.repo.nii.ac.jp/?action=repository_action_common_download&item_id=2689&item_no=1&attribute_id=22&file_no=1"}}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Honeycomb-shaped β-TCP","subitem_subject_scheme":"Other"},{"subitem_subject":"Atelocollagen","subitem_subject_scheme":"Other"},{"subitem_subject":"VEGF","subitem_subject_scheme":"Other"},{"subitem_subject":"Bone marrow mesenchymal stem cells","subitem_subject_scheme":"Other"},{"subitem_subject":"Blood vessels","subitem_subject_scheme":"Other"},{"subitem_subject":"Bone regeneration","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Atelocollagen enhanced osteogenesis in a geometricstructured beta–TCP scaffold by VEGF induction.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Atelocollagen enhanced osteogenesis in a geometricstructured beta–TCP scaffold by VEGF induction.","subitem_title_language":"en"}]},"item_type_id":"20002","owner":"25","path":["2719","2804","2811","2820","2826"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-04-01"},"publish_date":"2021-04-01","publish_status":"0","recid":"42669","relation_version_is_last":true,"title":["Atelocollagen enhanced osteogenesis in a geometricstructured beta–TCP scaffold by VEGF induction."],"weko_creator_id":"25","weko_shared_id":-1},"updated":"2023-05-15T17:53:00.592458+00:00"}