{"created":"2023-05-15T16:12:01.069534+00:00","id":42423,"links":{},"metadata":{"_buckets":{"deposit":"95877f47-95aa-4279-8a1b-84a79ca11d64"},"_deposit":{"created_by":25,"id":"42423","owners":[25],"pid":{"revision_id":0,"type":"depid","value":"42423"},"status":"published"},"_oai":{"id":"oai:shinshu.repo.nii.ac.jp:00042423","sets":["2668"]},"author_link":["165791","165786","165789","165787","165792","165785","165788","165790","165784"],"item_20002_biblio_info_27":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"357","bibliographicPageStart":"347","bibliographicVolumeNumber":"14","bibliographic_titles":[{"bibliographic_title":"CURRENT PROTEIN & PEPTIDE SCIENCE"}]}]},"item_20002_creator_3":{"attribute_name":"作成者(その他言語)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shindo, Takayuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sakurai, Takayuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kamiyoshi, Akiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ichikawa-Shindo, Yuka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shimoyama, Natsumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Iinuma, Nobuyoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Arai, Takuma"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miyagawa, Shinichi"}],"nameIdentifiers":[{}]}]},"item_20002_date_19":{"attribute_name":"日付","attribute_value_mlt":[{"subitem_date_issued_datetime":"2017-12-28","subitem_date_issued_type":"Created"}]},"item_20002_description_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Adrenomedullin (ADM), originally identified as a vasodilating peptide, is now recognized to be a pleiotropic molecule involved in both the pathogenesis of cardiovascular diseases and circulatory homeostasis. Homozygotes of ADM knockout mice (ADM-/-) were lethal at mid-gestation with abnormalities of vascular development and this finding clarified the angiogenic potency of ADM. Calcitonin gene-related peptide (CGRP), which has a structure and function similar to that of ADM, has been identified as a family peptide of ADM. Unlike ADM-/-, CGRP-/- were apparently normal. Therefore, the study of knockout mice first clarified the distinctly different physiological roles between ADM and CGRP. In contrast, heterozygotes of ADM knockout mice (ADM+/-) were alive but showed blood pressure elevation, reduced neovascularization, and enhanced neointimal formation by arterial injury. Based on these observations, there was hope ADM would have a therapeutic use. However, ADM has a short half-life in the blood stream and its application in chronic disease has limitations. Therefore, we focused on the ADM receptor system. The calcitonin-receptor-like receptor (CLR), which is the ADM receptor, associates with one of the accessory proteins, called receptor activity-modifying proteins (RAMPs). By interacting with RAMP1, CLR exhibits a high affinity for CGRP, whereas by interacting with either RAMP2 or -3, CLR exhibits a high affinity for ADM. We generated RAMP knockout mice and found that vascular phenotypes similar to ADM-/- were reproduced only in RAMP2-/-. This shows that RAMP2 is the key determinant of the vascular functions of ADM. RAMP2 could be an attractive therapeutic target in cardiovascular diseases.","subitem_description_type":"Other"}]},"item_20002_description_20":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_20002_description_22":{"attribute_name":"その他の資源識別子","attribute_value_mlt":[{"subitem_description":"CURRENT PROTEIN & PEPTIDE SCIENCE. 14(5):347-357 (2013)","subitem_description_type":"Other"}]},"item_20002_full_name_16":{"attribute_name":"公開者(その他言語)","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"BENTHAM, SCIENCE PUBL LTD"}]}]},"item_20002_identifier_23":{"attribute_name":"資源識別子URI","attribute_value_mlt":[{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/10091/00020112"}]},"item_20002_relation_31":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed&term=23745699","subitem_relation_type_select":"PMID"}}]},"item_20002_relation_32":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://doi.org/10.2174/13892037113149990052","subitem_relation_type_select":"DOI"}}]},"item_20002_rights_50":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2013 Bentham Science Publishers"},{"subitem_rights":"© 2013 Bentham Science Publishers"}]},"item_20002_source_id_25":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1389-2037","subitem_source_identifier_type":"ISSN"}]},"item_20002_source_id_26":{"attribute_name":"処理レコードID(総合目録DB)","attribute_value_mlt":[{"subitem_source_identifier":"AA11692455","subitem_source_identifier_type":"NCID"}]},"item_20002_version_type_51":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"url":{"url":"https://soar-ir.repo.nii.ac.jp/?action=repository_action_common_download&item_id=19351&item_no=1&attribute_id=65&file_no=1"}}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Adrenomedullin","subitem_subject_scheme":"Other"},{"subitem_subject":"receptor activity-modifying proteins","subitem_subject_scheme":"Other"},{"subitem_subject":"knockout mouse","subitem_subject_scheme":"Other"},{"subitem_subject":"angiogenesis","subitem_subject_scheme":"Other"},{"subitem_subject":"lymphangiogenesis","subitem_subject_scheme":"Other"},{"subitem_subject":"endothelial cell","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Regulation of Adrenomedullin and its Family Peptide by RAMP System - Lessons from Genetically Engineered Mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Regulation of Adrenomedullin and its Family Peptide by RAMP System - Lessons from Genetically Engineered Mice"}]},"item_type_id":"20002","owner":"25","path":["2668"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-03-01"},"publish_date":"2021-03-01","publish_status":"0","recid":"42423","relation_version_is_last":true,"title":["Regulation of Adrenomedullin and its Family Peptide by RAMP System - Lessons from Genetically Engineered Mice"],"weko_creator_id":"25","weko_shared_id":-1},"updated":"2023-05-15T17:56:19.202030+00:00"}