{"created":"2023-05-15T15:57:45.398234+00:00","id":27037,"links":{},"metadata":{"_buckets":{"deposit":"5d4ded1a-1fa0-4cd2-8cf9-c143fe906913"},"_deposit":{"created_by":3,"id":"27037","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"27037"},"status":"published"},"_oai":{"id":"oai:shinshu.repo.nii.ac.jp:00027037","sets":["2668"]},"author_link":["104882","104877","104883","104878","104881","104885","104886","104888","104887","104884","104879","104880"],"item_20002_biblio_info_27":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageEnd":"616","bibliographicPageStart":"613","bibliographicVolumeNumber":"56","bibliographic_titles":[{"bibliographic_title":"JOURNAL OF HUMAN GENETICS"}]}]},"item_20002_creator_3":{"attribute_name":"作成者(その他言語)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sasayama, Daimei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hori, Hiroaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Teraishi, Toshiya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hattori, Kotaro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ota, Miho"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsuo, Junko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawamoto, Yumiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kinoshita, Yukiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Higuchi, Teruhiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Amano, Naoji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kunugi, Hiroshi"}],"nameIdentifiers":[{}]}]},"item_20002_date_19":{"attribute_name":"日付","attribute_value_mlt":[{"subitem_date_issued_datetime":"2015-09-24","subitem_date_issued_type":"Created"}]},"item_20002_description_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Interleukin-1 beta (IL-1 beta) is considered to have a role in age-related cognitive decline. A recent study has shown that a promoter polymorphism of the IL-1 beta gene (rs16944) is associated with cognitive performance in elderly males without dementia. In this study, we examined whether polymorphisms of the IL-1 beta gene also influence cognitive functions in elderly females. Cognitive functions were assessed by the Wechsler adult intelligence scale-revised (WAIS-R) in 99 elderly (>= 60 years) females without dementia. We selected five tagging polymorphisms from the IL-1 beta gene and examined the associations with the WAIS-R scores. Significant associations were found between verbal intelligence quotient (IQ) and the genotypes of rs1143634 and rs1143633 (P = 0.0037 and P = 0.010, respectively). No significant associations of rs16944 genotype were found with verbal or performance IQ. However, individuals homozygous for the G allele of rs16944 achieved higher scores in digit span compared with their counterpart, which is consistent with the previous findings in males. These results suggest that IL-1 beta gene variation may have a role in cognitive functions in aging females as well as males. Journal of Human Genetics (2011) 56, 613-616; doi:10.1038/jhg.2011.56; published online 26 May 2011","subitem_description_type":"Other"}]},"item_20002_description_20":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_20002_description_22":{"attribute_name":"その他の資源識別子","attribute_value_mlt":[{"subitem_description":"JOURNAL OF HUMAN GENETICS. 56(8):613-616 (2011)","subitem_description_type":"Other"}]},"item_20002_full_name_16":{"attribute_name":"公開者(その他言語)","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"NATURE, PUBLISHING GROUP"}]}]},"item_20002_identifier_23":{"attribute_name":"資源識別子URI","attribute_value_mlt":[{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/10091/17724"}]},"item_20002_relation_31":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed&term=21614008","subitem_relation_type_select":"PMID"}}]},"item_20002_relation_32":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dx.doi.org/10.1038/jhg.2011.56","subitem_relation_type_select":"DOI"}}]},"item_20002_rights_50":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright© 2011 The Japan Society of Human Genetics"}]},"item_20002_source_id_25":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1434-5161","subitem_source_identifier_type":"ISSN"}]},"item_20002_source_id_26":{"attribute_name":"処理レコードID(総合目録DB)","attribute_value_mlt":[{"subitem_source_identifier":"AA11206160","subitem_source_identifier_type":"NCID"}]},"item_20002_version_type_51":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"url":{"url":"https://soar-ir.repo.nii.ac.jp/?action=repository_action_common_download&item_id=3691&item_no=1&attribute_id=65&file_no=1"}}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"cognitive function","subitem_subject_scheme":"Other"},{"subitem_subject":"genetic polymorphism","subitem_subject_scheme":"Other"},{"subitem_subject":"interleukin-1 beta","subitem_subject_scheme":"Other"},{"subitem_subject":"intelligence","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Association of interleukin-1 beta genetic polymorphisms with cognitive performance in elderly females without dementia","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Association of interleukin-1 beta genetic polymorphisms with cognitive performance in elderly females without dementia"}]},"item_type_id":"20002","owner":"3","path":["2668"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-09-01"},"publish_date":"2020-09-01","publish_status":"0","recid":"27037","relation_version_is_last":true,"title":["Association of interleukin-1 beta genetic polymorphisms with cognitive performance in elderly females without dementia"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T22:11:42.696545+00:00"}