{"created":"2023-05-15T15:57:45.333726+00:00","id":27036,"links":{},"metadata":{"_buckets":{"deposit":"5f71611d-df99-49e9-8622-ab1fe9fa24bc"},"_deposit":{"created_by":3,"id":"27036","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"27036"},"status":"published"},"_oai":{"id":"oai:shinshu.repo.nii.ac.jp:00027036","sets":["2668"]},"author_link":["104870","104871","104873","104872","104876","104866","104875","104868","104869","104874","104867"],"item_20002_biblio_info_27":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"358","bibliographicPageStart":"354","bibliographicVolumeNumber":"13","bibliographic_titles":[{"bibliographic_title":"PHARMACOGENOMICS JOURNAL"}]}]},"item_20002_creator_3":{"attribute_name":"作成者(その他言語)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sasayama, D"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hiraishi, A"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tatsumi, M"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kamijima, K"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ikeda, M"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Umene-Nakano, W"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshimura, R"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakamura, J"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Iwata, N"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kunugi, H"}],"nameIdentifiers":[{}]}]},"item_20002_date_19":{"attribute_name":"日付","attribute_value_mlt":[{"subitem_date_issued_datetime":"2015-09-24","subitem_date_issued_type":"Created"}]},"item_20002_description_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Association between response to antidepressant treatment and genetic polymorphisms was examined in two independent Japanese samples of patients with major depressive disorder (MDD). Genome-wide approach using the Illumina Human CNV370-quad Bead Chip was utilized in the analysis of the 92 MDD patients in the first sample. In all, 11 non-intergenic single-nucleotide polymorphisms with uncorrected allelic P-value <0.0001 were selected for the subsequent association analyses in the second sample of 136 MDD patients. Difference in allele distribution between responders and nonresponders were found in the second-stage sample for rs365836 and rs201522 of the CUX1 gene (P=0.005 and 0.004, respectively). The allelic P-values for rs365836 and rs201522 in both samples combined were 0.0000023 and 0.0000040, respectively. Our results provide the first evidence that polymorphisms of the CUX1 gene may be associated with response to antidepressant treatment in Japanese patients with MDD.","subitem_description_type":"Other"}]},"item_20002_description_20":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_20002_description_22":{"attribute_name":"その他の資源識別子","attribute_value_mlt":[{"subitem_description":"PHARMACOGENOMICS JOURNAL. 13(4):354-358 (2013)","subitem_description_type":"Other"}]},"item_20002_full_name_16":{"attribute_name":"公開者(その他言語)","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"NATURE, PUBLISHING GROUP"}]}]},"item_20002_identifier_23":{"attribute_name":"資源識別子URI","attribute_value_mlt":[{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/10091/17725"}]},"item_20002_relation_31":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed&term=22584459","subitem_relation_type_select":"PMID"}}]},"item_20002_relation_32":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dx.doi.org/10.1038/tpj.2012.18","subitem_relation_type_select":"DOI"}}]},"item_20002_source_id_25":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1470-269x","subitem_source_identifier_type":"ISSN"}]},"item_20002_source_id_26":{"attribute_name":"処理レコードID(総合目録DB)","attribute_value_mlt":[{"subitem_source_identifier":"AA11703518","subitem_source_identifier_type":"NCID"}]},"item_20002_version_type_51":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"url":{"url":"https://soar-ir.repo.nii.ac.jp/?action=repository_action_common_download&item_id=3690&item_no=1&attribute_id=65&file_no=1"}}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"antidepressant","subitem_subject_scheme":"Other"},{"subitem_subject":"CUX1","subitem_subject_scheme":"Other"},{"subitem_subject":"genome-wide association study","subitem_subject_scheme":"Other"},{"subitem_subject":"major depressive disorder","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Possible association of CUX1 gene polymorphisms with antidepressant response in major depressive disorder","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Possible association of CUX1 gene polymorphisms with antidepressant response in major depressive disorder"}]},"item_type_id":"20002","owner":"3","path":["2668"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-09-01"},"publish_date":"2020-09-01","publish_status":"0","recid":"27036","relation_version_is_last":true,"title":["Possible association of CUX1 gene polymorphisms with antidepressant response in major depressive disorder"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T22:11:43.694337+00:00"}