{"created":"2023-05-15T15:55:09.866216+00:00","id":23616,"links":{},"metadata":{"_buckets":{"deposit":"4c5606c6-3791-470e-b04c-e2a9fa0de05c"},"_deposit":{"created_by":1,"id":"23616","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"23616"},"status":"published"},"_oai":{"id":"oai:shinshu.repo.nii.ac.jp:00023616","sets":[]},"author_link":["95646","95645","95647","95651","95649","95644","95648","95652","95650"],"item_20003_alternative_title_1":{"attribute_name":"その他(別言語等)のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"多形腺腫における細胞分化の促進因子としての Wnt シグナルの可能性"}]},"item_20003_biblio_info_27":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-07-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"9","bibliographicPageEnd":"978","bibliographicPageStart":"971","bibliographicVolumeNumber":"11","bibliographic_titles":[{"bibliographic_title":"International journal of medical sciences"}]}]},"item_20003_creator_3":{"attribute_name":"作成者(その他言語)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Okuda, Yukiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Keisuke, Nakano"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Koji, Suzuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshihiko, Sugita"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Katsutoshi, Kubo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hatsuhiko, Maeda"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Norimasa, Okafuji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hiromasa, Hasegawa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Toshiyuki, Kawakami"}],"nameIdentifiers":[{}]}]},"item_20003_date_19":{"attribute_name":"日付","attribute_value_mlt":[{"subitem_date_issued_datetime":"2015-07-06","subitem_date_issued_type":"Created"}]},"item_20003_date_granted_56":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2015-02-05"}]},"item_20003_degree_grantor_58":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"松本歯科大学"}],"subitem_degreegrantor_identifier":[{}]}]},"item_20003_degree_name_57":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）"}]},"item_20003_description_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"There are well known that Wnt signaling was some roles of cell differentiation at the development tissues, especially the oral and maxillofacial regions of some developmental stages. Therefore, to determine Wnt signaling in the pleomorphic adenoma tissues, we examined. The expression of Wnt1 and β-catenin as well as the distribution of various cytoskeletal proteins CK7 and CK13 was examined in 30 cases of pleomorphic adenoma by immunohistochemistry. Wnt1 was detected in almost all tumor cells. The peripheral columnar cells in squamous metaplasia and small cuboidal cells in duct-like structures were strongly positive to Wnt1. Although β-catenin was clearly localized on the cell membrane of tumor cells, nuclear translocation was observed in small cuboidal cells and in some basaloid cells. The immunofluorescent staining pattern of Wnt1 and CK7 as well as Wnt1 and CK13 was consistent with IHC results. Thus, in pleomorphic adenoma, Wnt is involved in tumor cell differentiation of peripheral columnar cells forming solid nests and small peripheral columnar cells forming duct-like structures. Moreover, among the three currently known Wnt pathways, β-catenin is the suggested pathway working during cell differentiation. Furthermore, peripheral columnar cells in solid tumor nests and in squamous metaplasia are governed by another Wnt pathway other than β-catenin. Therefore, Wnt signaling through β-catenin pathway may be involved in the ‘mixed’ differentiation characteristic of pleomorphic adenoma although another pathway may also be possibly working in other parts of the tumor tissue.","subitem_description_type":"Other"},{"subitem_description":"2014","subitem_description_type":"Other"}]},"item_20003_description_21":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_20003_description_22":{"attribute_name":"その他の資源識別子","attribute_value_mlt":[{"subitem_description":"甲第162号","subitem_description_type":"Other"}]},"item_20003_dissertation_number_55":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第162号"}]},"item_20003_identifier_23":{"attribute_name":"資源識別子URI","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"http://id.nii.ac.jp/1070/00002398/"}]},"item_20003_relation_28":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"雑誌掲載論文(電子版)"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"http://www.medsci.org/v11p0971.htm"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113590/"}]}]},"item_20003_relation_31":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"info:pmid/25076852","subitem_relation_type_select":"PMID"}}]},"item_20003_relation_32":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.7150/ijms.9453","subitem_relation_type_select":"DOI"}}]},"item_20003_rights_50":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited."}]},"item_20003_source_id_25":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1449-1907","subitem_source_identifier_type":"ISSN"}]},"item_20003_source_id_26":{"attribute_name":"処理レコードID(総合目録DB)","attribute_value_mlt":[{"subitem_source_identifier":"AA1197928X","subitem_source_identifier_type":"NCID"}]},"item_20003_version_type_51":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"url":{"url":"https://mdu.repo.nii.ac.jp/?action=repository_action_common_download&item_id=2410&item_no=1&attribute_id=20&file_no=1"}},{"url":{"url":"https://mdu.repo.nii.ac.jp/?action=repository_action_common_download&item_id=2410&item_no=1&attribute_id=20&file_no=2"}}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"pleomorphic adenoma","subitem_subject_scheme":"Other"},{"subitem_subject":"Wnt signaling","subitem_subject_scheme":"Other"},{"subitem_subject":"β-catenin","subitem_subject_scheme":"Other"},{"subitem_subject":"cytokeratin","subitem_subject_scheme":"Other"},{"subitem_subject":"immunohistochemistry","subitem_subject_scheme":"Other"},{"subitem_subject":"cell differentiation","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Wnt signaling as a possible promoting factor of cell differentiation in pleomorphic adenomas","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Wnt signaling as a possible promoting factor of cell differentiation in pleomorphic adenomas","subitem_title_language":"en"}]},"item_type_id":"20003","owner":"1","path":["2589"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-11-10"},"publish_date":"2022-11-10","publish_status":"0","recid":"23616","relation_version_is_last":true,"title":["Wnt signaling as a possible promoting factor of cell differentiation in pleomorphic adenomas"],"weko_creator_id":"1","weko_shared_id":1},"updated":"2023-05-15T18:14:15.333268+00:00"}