@article{oai:shinshu.repo.nii.ac.jp:00002293,
 author = {川上, 敏行 and 中村, 千仁 and 宇治, 英世 and 長谷川, 博雅 and 枝, 重夫},
 issue = {2},
 journal = {松本歯学},
 month = {Aug},
 note = {Using a ^<14>C-labeled compound, the fate of the silicone oil component of the root canal filling material "Vitapex" embedded in subcutaneous tissue was investigated. Under general anesthesia, a total of 500 mg of paste (500 μCi of ^<14>C) was embedded in the dorsal subcutaneous connective tissue of a rat. The animal was kept in a metabolic cage during the experimental period. The feces and urine were collected every day. Thirteen days after embedding, the animal was killed and organs were taken. Radioactivity of the feces, urine, and organs was measured with a liquid scintillation spectrometer. The results are as follows. Some of the ^<14>C compound was excreted in the feces and urine. The amount excreted in the feces averaged 3.1217 × 10^<-2> μCi/day, and the total amount over the experimental period (13 days) was 4.5818 × 10^<-1> μCi. In the urine, the ^<14>C level averaged about 10-fold less, or 3.6646 × 10^<-3> μCi/day, and 4.7640 × 10^<-2> μCi was excreted over the experimental period. The total amount excreted by the animal (in feces and urine) was thus 5.0583 × 10^<-1> μCi, equal to about 0.1% of the total dose (500 μCi) embedded. Further, the ^<14>C-labeled compound was found distributed in many tissues and organs, such as the skin, kidney, bladder, liver, bone, digestive tract, blood, adrenal gland, and spleen., application/pdf},
 pages = {167--172},
 title = {ラットの皮下組織内に埋入した根管充塡材中のシリコーン・オイルの動態},
 volume = {15},
 year = {1989}
}