@article{oai:shinshu.repo.nii.ac.jp:00002047,
 author = {豊城, あずさ and 岡藤, 範正 and 芦澤, 雄二 and 松田, 泰明 and 出口, 敏雄 and 長谷川, 敬保 and 佐原, 紀行 and 鈴木, 和夫},
 issue = {3},
 journal = {松本歯学},
 month = {Dec},
 note = {Orthodontic treatment commonly causes apical root resorption (AP). Especially, duration of intrusive force have a significant associaion with AP. However, there has been a little information concerning about the histological changes of periodontal tissues during continuous intrusion of tooth. The aim of this study was to evaluate changes of periodontal tissues during experimental intrusive force by histological and histochemical techniques. Intrusive force by labial-arch appliance on the maxillary left central and lateral incisors of male Japanese monkeys (Macaca fusucata) were applied on 1, 3, and 6 months. After three different experimental durations, maxillary anterior bone segments were dissected out, decalcified, and prepared for histochemical study. One month after treatment, many resorption lacunae were found not only apical but lateral surface of the roots. Numerous mononuclear and multinucleate cells which showed tartrate resistant acid phosphatase (TRAP) activity were observed adjacent to the resorpted root surface. After 3 months, most of the resorption lacunae of lateral root surface had been repaired. In the apical resion, However, TRAP positive cells were observed on the root and alveolar bone. The periodontal membrane space was significantly widen. Numerous blood vesseles occupaied the space of periodontal menbrane. These histological configurations were also found after 6 month treatment. The present study suggested that intrusive force might continuously stimulate resorptive activity in apical region of teeth, and induce AP., application/pdf},
 pages = {265--273},
 title = {実験的歯の圧下時に伴う歯根尖吸収 : 組織化学的観察},
 volume = {20},
 year = {1994}
}