@article{oai:shinshu.repo.nii.ac.jp:00001839,
 author = {川上, 敏行},
 issue = {2-3},
 journal = {松本歯学},
 month = {Dec},
 note = {Bone morphogenetic protein (BMP) is an important bioactive protein. BMP was first described by Urist (1965) and has been investigated for its heterotopic osteogenetic properties. rhBMP has been identified by genetic engineering techniques and the time will come when BMP can be synthesized in large quantities and used in clinical practice such as in dental fields. It is well known that a proper carrier is neccessary for BMP delivery system. Many materials, such as insoluble bone matrix, collagen and ceramics have been tested as BMP carriers. It has been stated that BMP induces undifferentiated mesenchymal cells to became chondrocytes in the first stage of the BMP-induced heterotopic osteogenesis. The cartilage is replaced by bone in a manner similar to that of normal endochondral ossification. It is suggested that the BMP-induced bone occurs through an endochondral-like ossification; however, the cell differentiation patterns differ from those of the normal endochondral ossification process. On the other hand, intramembranous ossification is observed in some cases. These reports indicate the intramembranous and endochondral ossification occurred independently in both composite systems. Our histopathological, histochemical, immunohistochemical and in situ hybridization findings of BMP-induced heterotopic osteogenesis are as follows: The examining histopathological features of chondroid bone are more like bone than cartilage, but cells in the chondroid bone matrix were not distinguishable from chondrocytes. Round chondrocytes-like cells and smaller osteocyte-like cells coexisted in the chondroid bone matrix. Both typical matrix proteins of cartilage (type II collagen) and bone (type I collagen and osteocalcin) were detected in the matrix of "chondroid bone" in the early phase of BMP-induced heterotopic osteogenesis. These results seem to be a third ossification pattern, "transchondroid bone formation". Furthermore, BMP was suggested to be applicable in clinical dental practice if a suitable and delivery system can be utilized at a future date., application/pdf},
 pages = {101--112},
 title = {骨形成因子(BMP)と骨形成},
 volume = {25},
 year = {1999}
}