{"created":"2023-05-15T15:49:41.058956+00:00","id":1615,"links":{},"metadata":{"_buckets":{"deposit":"2551af95-6eb6-4d60-914d-f3127a618384"},"_deposit":{"created_by":3,"id":"1615","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"1615"},"status":"published"},"_oai":{"id":"oai:shinshu.repo.nii.ac.jp:00001615","sets":[]},"author_link":["4331","4332","4333"],"item_20002_alternative_title_1":{"attribute_name":"その他(別言語等)のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Histological changes and clinical outcomes after gamma knife surgery"}]},"item_20002_biblio_info_27":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006-12-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"198","bibliographicPageStart":"188","bibliographicVolumeNumber":"32","bibliographic_titles":[{"bibliographic_title":"松本歯学"}]}]},"item_20002_creator_2":{"attribute_name":"作成者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"富田, 美穂子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"林, 基弘"}],"nameIdentifiers":[{}]}]},"item_20002_date_19":{"attribute_name":"日付","attribute_value_mlt":[{"subitem_date_issued_datetime":"2012-05-24","subitem_date_issued_type":"Created"}]},"item_20002_description_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Gamma knife surgery (GKS) has been increasingly utilized to manage a wide variety of indications including arteriovenous malformations, brain tumors, Parkinson disease, or focal epilepsy. In clinical, practice, GKS is thought to be a safe and effective treatment for these diseases, even if patients are old or at high risk; however, little is understood about the alteration of biological properties induced by gamma irradiation during procedures using this device. In recent studies using animals, it has been shown that low-dose gamma irradiation promotes survival of injured neurons in the central nervous system via homeostasis-driven proliferation of T cells, whereas a high dose causes marked degeneration of the capillary endothelial cells, consequently inducing edema and necrosis in the irradiated area. More recently, GKS has also been employed to treat intractable pain control, such as trigeminal neuralgia, thalamic pain and cancer pain. Some investigators have suggested that gamma irradiation may relieve completely these pains by increasing the levels of β-en-dorphin in both blood and cerebrospinal fluid. Thus, it is very important to conduct further basic experiments to determine the optimal treatment protocol using GKS for various diseases across many fields.","subitem_description_type":"Other"}]},"item_20002_description_21":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_20002_full_name_16":{"attribute_name":"公開者(その他言語)","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"松本歯科大学学会"}]}]},"item_20002_identifier_23":{"attribute_name":"資源識別子URI","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"http://id.nii.ac.jp/1070/00000469/"}]},"item_20002_source_id_25":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0385-1613","subitem_source_identifier_type":"ISSN"}]},"item_20002_source_id_26":{"attribute_name":"処理レコードID(総合目録DB)","attribute_value_mlt":[{"subitem_source_identifier":"AN00232590","subitem_source_identifier_type":"NCID"}]},"item_20002_version_type_51":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"url":{"url":"https://mdu.repo.nii.ac.jp/?action=repository_action_common_download&item_id=469&item_no=1&attribute_id=22&file_no=1"}}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ガンマナイフ","subitem_subject_scheme":"Other"},{"subitem_subject":"放射線治療","subitem_subject_scheme":"Other"},{"subitem_subject":"三叉神経痛","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ガンマナイフによる組織変化と臨床応用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ガンマナイフによる組織変化と臨床応用"}]},"item_type_id":"20002","owner":"3","path":["2360"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-11-10"},"publish_date":"2022-11-10","publish_status":"0","recid":"1615","relation_version_is_last":true,"title":["ガンマナイフによる組織変化と臨床応用"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-05-15T19:48:59.911342+00:00"}