@article{oai:shinshu.repo.nii.ac.jp:00001265, author = {梅村, 恭伸 and 田所, 治 and 宇都野, 創}, issue = {1}, journal = {松本歯学}, month = {Apr}, note = {To determine the precise distribution of autonomic nerve fibers in human labial glands, tyrosine hydroxylase (TH) was used as a marker of sympathetic nerve fibers and vasoactive intestinal polypeptide (VIP) as a marker of parasympathetic fibers. Then immunohistochemical localizations of nerve fibers stained by TH and VIP were examined in the human labial glands. VIP-immunopositive nerve fibers were detected around the acini and blood vessels. TH-immunopositive nerve fibers were found not only around the blood vessels but also close to the acini, although there was individual variation. In addition, TH-positive nerve fibers were more abundant around the serous acini than around the mucous acini. However, VIP-immunopositive nerve fibers showed almost the same distribution around both the serous and mucous acini. These results about the parasympathetic nerve fibers were in agreement with the results of previous reports. However, unlike the previous papers, sympathetic nerve fibers were found not only around the blood vessels, but also very close around the acini. Most of the TH and VIP-immunopositive nerve fibers were found in proximity to the basement membrane of the acinar cells, but VIP-immunopositive nerve fibers were occasionally found the intercellular space between acinar cells after penetrating the basement membrane. Most of the sympathetic and parasympathetic fibers were the epilemmal type, so that, most acinar cells were separated from nerve fibers by the basement membrane. Both TH and VIP-immunopositive nerve fibers were found among fibers in the nerve bundle coursing through the connective tissue around the human labial gland. Together with the findings of previous studies, this study strongly suggests that sympathetic nerve fibers are distributed in the human labial gland via the trigeminal nerve, along with the distribution of the parasympathetic nerve fibers., application/pdf}, pages = {8--16}, title = {ヒト口唇腺の自律神経線維の免疫組織化学的局在について}, volume = {35}, year = {2009} }