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Human acid-insoluble dentin with BMP-2 accelerates bone induction in subcutaneous and intramuscular tissues
https://shinshu.repo.nii.ac.jp/records/44429
https://shinshu.repo.nii.ac.jp/records/44429119e15cf-a953-4652-a943-5f2f258aaa74
名前 / ファイル | ライセンス | アクション |
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https://mdu.repo.nii.ac.jp/?action=repository_action_common_download&item_id=2829&item_no=1&attribute_id=22&file_no=1
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Item type | Journal Article(1) | |||||
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公開日 | 2021-04-01 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Human acid-insoluble dentin with BMP-2 accelerates bone induction in subcutaneous and intramuscular tissues | |||||
その他(別言語等)のタイトル | ||||||
その他のタイトル | 皮下組織および筋間組織におけるBMP‐2促進骨誘導によるヒト酸不溶性象牙質 | |||||
作成者(その他言語) |
MURATA, Masaru
× MURATA, Masaru× KAWAI, Tatsushi× KAWAKAMI, Toshiyuki× AKAZAWA, Toshiyuki× TAZAKI, Junichi× ITO, Katsutoshi× KUSANO, Kaoru× ARISUE, Makoto× 村田, 勝× 河合, 達志× 川上, 敏行× 赤澤, 敏之× 田崎, 純一× 伊藤, 勝敏× 草野, 薫× 有末, 真 |
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公開者(その他言語) | ||||||
姓名 | 公益社団法人, 日本セラミックス協会 | |||||
書誌情報 |
Journal of the ceramic society of JAPAN 巻 118, 号 1378, p. 438-441-441, 発行日 2010 |
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言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | バイオセラミック | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 歯科用材料 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 象牙質 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 不溶性 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | コラーゲン | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 生体適合性 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 骨形成 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 除去 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 歯根 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 移植 動物 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 硬組織 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 骨形成因子 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 蛋白質 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 皮下組織 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | バイオアッセイ | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | キャリア | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 骨誘導 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 骨誘導性 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 脱ミネラル | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | BMP‐2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 担体 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Human | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Dentin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Demineralization | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Bone Induction | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | BMP-2 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Dentin matrix is well known as the most insoluble collagen in human body. We already confirmed the osteoinductive property by granules of human demineralized dentin matrix (DDM) histologically. Human DDM granules and human demineralized root-dentin (DRD) mass were prepared from adult vital teeth. The hard tissue induction by DDM alone or DRD alone was estimated at 4 weeks after implantation. The DDM alone induced bone and cartilage independently. In addition, the bioassay by recombinant human BMP-2 (5.0 .MU.g)/DDM or BMP-2 (5.0 .MU.g)/DRD was estimated in mouse subcutaneous or intramuscular tissues, respectively. Histological examination showed that the BMP-2/DDM induced bone and marrow, and the DDM granules were partially absorbed by new bone. The morphometric analysis demonstrated that the BMP-2/DDM showed 36.3% in the volume of bone and marrow, while the DDM alone showed 1.3% at 4 weeks. Moreover, the BMP-2/DRD also induced active bone formation on the root surface and in the pulp cavity. These results indicate that BMP-2 significantly accelerated bone formation in decalcified dentin implants. Human recycled DDM and DRD might be effective materials as osteoinductive collagenous carriers of BMP-2 for bone engineering. (Author abst.) | |||||
日付 | ||||||
日付 | 2019-04-25 | |||||
日付タイプ | Created | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
資源識別子URI | ||||||
識別子 | http://id.nii.ac.jp/1070/00002819/ | |||||
識別子タイプ | URI | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1882-0743 | |||||
処理レコードID(総合目録DB) | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA12229489 | |||||
情報源 | ||||||
関連名称 | https://doi.org/10.2109/jcersj2.118.438 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.2109/jcersj2.118.438 | |||||
権利 | ||||||
権利情報 | © 2010 The Ceramic Society of Japan. licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.(https://creativecommons.org/licenses/by-nd/4.0/) | |||||
権利 | ||||||
権利情報 | CC BY-ND | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |