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Deletion of Lrp4 increases the incidence of microphthalmia
https://shinshu.repo.nii.ac.jp/records/43879
https://shinshu.repo.nii.ac.jp/records/4387957f2576e-ff30-4d35-99c7-22fed3cdc1da
名前 / ファイル | ライセンス | アクション |
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https://soar-ir.repo.nii.ac.jp/?action=repository_action_common_download&item_id=20278&item_no=1&attribute_id=65&file_no=1
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Item type | Journal Article(1) | |||||
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公開日 | 2020-09-04 | |||||
タイトル | ||||||
タイトル | Deletion of Lrp4 increases the incidence of microphthalmia | |||||
作成者(その他言語) |
Tanahashi, Hiroshi
× Tanahashi, Hiroshi× Suzuki, Tatsuo |
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公開者(その他言語) | ||||||
姓名 | Elsevier, Inc. | |||||
書誌情報 |
Biochemical and Biophysical Research Communications 巻 506, 号 3, p. 478-484, 発行日 2018-11-30 |
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言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | BMP | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Coloboma | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Fold | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Microphthalmia | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | SHH | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | WNT | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Microphthalmia is a malformation that reduces the size of the ocular globe. The etiologies of this anomaly are various, but the genetic background appears to have a predominant influence on its development through mutations of genes controlling ocular developmental processes. LRP4 is a type I single transmembrane protein that is essential for the formation of neuromuscular junctions. We created and experimented on homozygous Lrp4-deficient mice and found the microphthalmia phenotype in their eyes. The loss of Lrp4 resulted in an elevated incidence of microphthalmia and affected the mRNA expression of the members of bone morphogenetic protein, fibroblast growth factor, Sonic hedgehog, and WNT signaling pathways and of several pathogenic genes for microphthalmia. Moreover, the loss of Lrp4 enhanced the incidence of aberrant retinal folds, which appeared pleated and corrugated in the eyeball. | |||||
日付 | ||||||
日付 | 2018-11-16 | |||||
日付タイプ | Created | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
その他の資源識別子 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Biochemical and Biophysical Research Communications. 506(2018) | |||||
資源識別子URI | ||||||
識別子 | http://hdl.handle.net/10091/00021036 | |||||
識別子タイプ | HDL | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0006-291x | |||||
処理レコードID(総合目録DB) | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00564395 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | https://www.ncbi.nlm.nih.gov/pubmed/30352686 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1016/j.bbrc.2018.10.062 | |||||
権利 | ||||||
権利情報 | © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
権利 | ||||||
権利情報 | © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa |