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Ectopic automaticity induced in ventricular myocytes by transgenic overexpression of HCN2
https://shinshu.repo.nii.ac.jp/records/43852
https://shinshu.repo.nii.ac.jp/records/43852657b6cd3-d73a-4981-91c1-447298239bec
名前 / ファイル | ライセンス | アクション |
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https://soar-ir.repo.nii.ac.jp/?action=repository_action_common_download&item_id=20251&item_no=1&attribute_id=65&file_no=1
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Item type | Journal Article(1) | |||||
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公開日 | 2020-09-04 | |||||
タイトル | ||||||
タイトル | Ectopic automaticity induced in ventricular myocytes by transgenic overexpression of HCN2 | |||||
作成者(その他言語) |
Oshita, Kensuke
× Oshita, Kensuke× Ltoh, Masayuki× Hirashima, Shingo× Kuwabara, Yoshihiro× Lshihara, Keiko× Kuwahara, Koichiro× Nakao, Kazuwa× Kimura, Takeshi× Nakamura, Kei-ichiro× Ushijima, Kazuo× Takano, Makoto |
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公開者(その他言語) | ||||||
姓名 | ELSEVIER, SCI LTD | |||||
書誌情報 |
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 巻 80, p. 81-89, 発行日 2015-01-03 |
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言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | HCN2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Arrhythmia | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Ion channel | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cardiomyocyte | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Electrophysiology | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Hyperpolarization-activated cyclic nucleotide-gated channels (HCNs) are expressed in the ventricles of fetal hearts but are normally down-regulated as development progresses. In the hypertrophied heart, however, these channels are re-expressed and generate a hyperpolarization-activated, nonselective cation current (Ih), which evidence suggests may increase susceptibility to arrhythmia. To test this hypothesis, we generated and analyzed transgenic mice overexpressing HCN2 specifically in their hearts (HCN2-Tg). Under physiological conditions, HCN2-Tg mice exhibited no discernible abnormalities. After the application of isoproterenol (ISO), however, ECG recordings from HCN2-Tg mice showed intermittent atrioventricular dissociation followed by idioventricular rhythm. Consistent with this observation, 0.3 μmol/L ISO-induced spontaneous action potentials (SAPs) in 76% of HCN2-Tg ventricular myocytes. In the remaining 24%, ISO significantly depolarized the resting membrane potential (RMP), and the late repolarization phase of evoked action potentials (APs) was significantly longer than in WT myocytes. Analysis of membrane currents revealed that these differences are attributable to the Ih tail current. These findings suggest HCN2 channel activity reduces the repolarization reserve of the ventricular action potential and increases ectopic automaticity under pathological conditions such as excessive β-adrenergic stimulation. | |||||
日付 | ||||||
日付 | 2018-11-01 | |||||
日付タイプ | Created | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
その他の資源識別子 | ||||||
内容記述タイプ | Other | |||||
内容記述 | JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY. 80: 81-89(2015) | |||||
資源識別子URI | ||||||
識別子 | http://hdl.handle.net/10091/00021009 | |||||
識別子タイプ | HDL | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0022-2828 | |||||
処理レコードID(総合目録DB) | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00702819 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | https://www.ncbi.nlm.nih.gov/pubmed/25562801 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1016/j.yjmcc.2014.12.019 | |||||
権利 | ||||||
権利情報 | © 2015 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) | |||||
権利 | ||||||
権利情報 | © 2015 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |