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Lysine Fermentation: History and Genome Breeding
https://shinshu.repo.nii.ac.jp/records/43421
https://shinshu.repo.nii.ac.jp/records/434219c369d1b-1cf1-4b8e-8c3b-be1a671a2874
名前 / ファイル | ライセンス | アクション |
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https://soar-ir.repo.nii.ac.jp/?action=repository_action_common_download&item_id=19990&item_no=1&attribute_id=65&file_no=1
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Item type | Journal Article(1) | |||||
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公開日 | 2020-09-04 | |||||
タイトル | ||||||
タイトル | Lysine Fermentation: History and Genome Breeding | |||||
作成者(その他言語) |
Ikeda, Masato
× Ikeda, Masato |
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公開者(その他言語) | ||||||
姓名 | SPRINGER, JAPAN | |||||
書誌情報 |
AMINO ACID FERMENTATION 巻 159, p. 73-102, 発行日 2017 |
|||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Corynebacterium glutamicum | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Downstream processing | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Escherichia coli | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Genome breeding | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Lysine market | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Lysine-producing strains | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Lysine production technology | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Product forms | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Systems metabolic engineering | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Lysine fermentation by Corynebacterium glutamicum was developed in 1958 by Kyowa Hakko Kogyo Co. Ltd. (current Kyowa Hakko Bio Co. Ltd.) and is the second oldest amino acid fermentation process after glutamate fermentation. The fundamental mechanism of lysine production, discovered in the early stages of the process's history, gave birth to the concept known as "metabolic regulatory fermentation,"which is now widely applied to metabolite production. After the development of rational metabolic engineering, research on lysine production first highlighted the need for engineering of the central metabolism from the viewpoints of precursor supply and NADPH regeneration. Furthermore, the existence of active export systems for amino acids was first demonstrated for lysine in C. glutamicum, and this discovery has resulted in the current recognition of such exporters as an important consideration in metabolite production. Lysine fermentation is also notable as the first process to which genomics was successfully applied to improve amino acid production. The first global "genome breeding" strategy was developed using a lysine producer as a model; this has since led to new lysine producers that are more efficient than classical industrial producers. These advances in strain development technology, combined with recent systems-level approaches, have almost achieved the optimization of entire cellular systems as cell factories for lysine production. In parallel, the continuous improvement of the process has resulted not only in fermentation processes with reduced load on downstream processing but also in commercialization of various product forms according to their intended uses. Nowadays lysine fermentation underpins a giant lysine demand of more than 2 million metric tons per year. | |||||
日付 | ||||||
日付 | 2018-07-24 | |||||
日付タイプ | Created | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
その他の資源識別子 | ||||||
内容記述タイプ | Other | |||||
内容記述 | In: Yokota A., Ikeda M. (eds) Amino Acid Fermentation. Advances in Biochemical Engineering/Biotechnology, 159:73-102 (2017) | |||||
資源識別子URI | ||||||
識別子 | http://hdl.handle.net/10091/00020751 | |||||
識別子タイプ | HDL | |||||
ISBN | ||||||
識別子タイプ | ISBN | |||||
関連識別子 | 978-4-431-56518-5 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0724-6145 | |||||
処理レコードID(総合目録DB) | ||||||
識別子タイプ | NCID | |||||
関連識別子 | BB23761867 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | http://doi.org/10.1007/10_2016_27 | |||||
権利 | ||||||
権利情報 | Copyright © Springer International Publishing Switzerland 2016 | |||||
権利 | ||||||
権利情報 | Copyright © Springer International Publishing Switzerland 2016 | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa |