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Gd-EOB-DTPA造影MRIによる定量的肝機能評価
https://shinshu.repo.nii.ac.jp/records/42419
https://shinshu.repo.nii.ac.jp/records/42419ee205cd3-7d98-4b8a-95a7-32f50d4b2d69
名前 / ファイル | ライセンス | アクション |
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https://soar-ir.repo.nii.ac.jp/?action=repository_action_common_download&item_id=19347&item_no=1&attribute_id=65&file_no=1
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Item type | Journal Article(1) | |||||
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公開日 | 2020-09-04 | |||||
タイトル | ||||||
タイトル | Gd-EOB-DTPA造影MRIによる定量的肝機能評価 | |||||
その他(別言語等)のタイトル | ||||||
その他のタイトル | Quantitative Evaluation of Liver Function with Use of Gd-EOBDTPA-Enhanced Magnetic Resonance Imaging | |||||
作成者(その他言語) |
山田, 哲
× 山田, 哲 |
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公開者(その他言語) | ||||||
姓名 | バイエル薬品 | |||||
書誌情報 |
日独医報 巻 58, 号 2, p. 49-56, 発行日 2013 |
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言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The quantitative evaluation of liver function is important not only for its monitoring but also for the preoperative evaluation of liver reserve. Indocyanin green (ICG) clearance has been used for reliable quantitative liver function test; however, ICG clearance cannot evaluate segmental liver function. Gd-EOB-DTPA is a bolus-injectable paramagnetic contrast medium taken into hepatocytes via organic anion-transporting polypeptide (OATP) specifically expressed on the cell membrane of hepatocytes; therefore, quantitative evaluation of segmental liver function using Gd-EOB-DTPAenhanced MR imaging could be feasible. The methods for quantitative evaluation of liver function using Gd-EOB-DTPA-enhanced MR imaging can be divided into two major categories: dynamic and static methods. In dynamic methods, time-intensity curve obtained from dynamic contrast-enhanced MR imaging is analyzed using various pharmacokinetic models. Compartment model analysis and deconvolution analysis are representative methods categorized as dynamic model-dependent analysis and dynamic model-independent analysis, respectively. Various parameters can be obtained by these dynamic methods; however, data acquisition and data analysis are complicated compared with those in static methods. In static methods, post-contrast-enhanced images, usually at the hepatobiliary phase, are analyzed using relaxation time or signal intensity of the liver. These static methods are easy to apply in clinical practice. The hepatocellular uptake index (HUI) is a static signal intensity-based method, which is derived from the signal intensities and volumes of the liver and spleen on Gd-EOB-DTPA-enhanced MR images at the hepatobiliary phase. HUI is the only currently available method that can evaluate segmental liver function quantitatively with proven correlation with reliable quantitative liver function tests such as ICG clearance. HUI is useful in the preoperative evaluation of liver reserve prior to transcatheter arterial chemoembolization (TACE) or hepatectomy. In this article, the pharmacokinetics of Gd-EOB-DTPA is first described using the compartment model. Then, derivations of the dual-inlet two-compartment uptake model and HUI are shown as examples of quantitative evaluation of liver function using Gd-EOB-DTPA-enhanced MR imaging. Finally, clinical application of HUI in TACE and hepatectomy is introduced. | |||||
日付 | ||||||
日付 | 2017-12-25 | |||||
日付タイプ | Created | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
その他の資源識別子 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 日独医報. 58(2):49-56 (2013) | |||||
資源識別子URI | ||||||
識別子 | http://hdl.handle.net/10091/00020108 | |||||
識別子タイプ | HDL | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0912-0351 | |||||
処理レコードID(総合目録DB) | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00184192 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |