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Association analysis of toll-like receptor 4 polymorphisms in Japanese primary biliary cirrhosis
https://shinshu.repo.nii.ac.jp/records/42118
https://shinshu.repo.nii.ac.jp/records/421184a67853a-c420-4004-87da-afc48233428e
名前 / ファイル | ライセンス | アクション |
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https://soar-ir.repo.nii.ac.jp/?action=repository_action_common_download&item_id=19058&item_no=1&attribute_id=65&file_no=1
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Item type | Journal Article(1) | |||||
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公開日 | 2020-09-04 | |||||
タイトル | ||||||
タイトル | Association analysis of toll-like receptor 4 polymorphisms in Japanese primary biliary cirrhosis | |||||
作成者(その他言語) |
Morita, Susumu
× Morita, Susumu× Joshita, Satoru× Umemura, Takeji× Katsuyama, Yoshihiko× Kimura, Takefumi× Komatsu, Michiharu× Matsumoto, Akihiro× Yoshizawa, Kaname× Kamijo, Atsushi× Yamamura, Nobuyoshi× Tanaka, Eiji× Ota, Masao |
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公開者(その他言語) | ||||||
姓名 | ELSEVIER, SCIENCE INC | |||||
書誌情報 |
HUMAN IMMUNOLOGY 巻 74, 号 2, p. 219-222, 発行日 2013-02 |
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言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Primary biliary cirrhosis (PBC) is characterized by portal inflammation and immune-mediated destruction of intrahepatic bile ducts that often result in liver failure. Toll-like receptor (TLR) 4 recognizes lipopolysaccharides of Gram-negative bacteria. Infectious agents have been suspected to play a crucial role in PBC pathogenesis since TLR4 expression was found in bile duct epithelial cells and periportal hepatocytes in liver tissues of PBC. To assess the potential contribution of TLR4 SNPs to the development of this disease, we genotyped five SNPs in TLR4 in 261 PBC patients and 359 controls using a TaqMan assay. No significant positive associations with either PBC susceptibility or progression were uncovered. These results indicate that TLR4 polymorphisms do not play a prominent role in the development of PBC in Japanese patients. (C) 2012 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved. | |||||
日付 | ||||||
日付 | 2017-09-20 | |||||
日付タイプ | Created | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
その他の資源識別子 | ||||||
内容記述タイプ | Other | |||||
内容記述 | HUMAN IMMUNOLOGY. 74(2):219-222 (2013) | |||||
資源識別子URI | ||||||
識別子 | http://hdl.handle.net/10091/00019820 | |||||
識別子タイプ | HDL | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0198-8859 | |||||
処理レコードID(総合目録DB) | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00214087 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed&term=23142582 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | http://doi.org/10.1016/j.humimm.2012.10.022 | |||||
権利 | ||||||
権利情報 | © 2013. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
権利 | ||||||
権利情報 | © 2013. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa |