| Item type |
Journal Article(1) |
| 公開日 |
2021-03-01 |
| タイトル |
|
|
タイトル |
Elucidation mechanism of different biological responses to multi-walled carbon nanotubes using four cell lines |
| 作成者(その他言語) |
Haniu, Hisao
Saito, Naoto
Matsuda, Yoshikazu
Kim, Yoong-Ahm
Park, Ki Chul
Tsukahara, Tamotsu
Usui, Yuki
Aoki, Kaoru
Shimizu, Masayuki
Ogihara, Nobuhide
Hara, Kazuo
Takanashi, Seiji
Okamoto, Masanori
Ishigaki, Norio
Nakamura, Koichi
Kato, Hiroyuki
|
| 公開者(その他言語) |
|
|
|
姓名 |
Dove, Medical Press |
| 書誌情報 |
International Journal of Nanomedicine
巻 1,
号 6,
p. 3487-3497,
発行日 2011-12-21
|
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
ulti-walled carbon nanotubes |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
cytotoxicity |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
endocytosis |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
cytokine secretion |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
reactive oxygen species |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
metadata only access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_14cb |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
We examined differences in cellular responses to multi-walled carbon nanotubes (MWCNTs) using malignant pleural mesothelioma cells (MESO-1), bronchial epithelial cells (BEAS-2B), neuroblastoma cells (IMR-32), and monoblastic cells (THP-1), before and after differentiation. MESO-1, BEAS-2B and differentiated THP-1 cells actively endocytosed MWCNTs, resulting in cytotoxicity with lysosomal injury. However, cytotoxicity did not occur in IMR-32 or undifferentiated THP-1 cells. Both differentiated and undifferentiated THP-1 cells exhibited an inflammatory response. Carbon blacks were endocytosed by the same cell types without lysosomal damage and caused cytokine secretion, but they did not cause cytotoxicity. These results indicate that the cytotoxicity of MWCNTs requires not only cellular uptake but also lysosomal injury. Furthermore, it seems that membrane permeability or cytokine secretion without cytotoxicity results from several active mechanisms. Clarification of the cellular recognition mechanism for MWCNTs is important for developing safer MWCNTs. |
| 日付 |
|
|
日付 |
2015-09-18 |
|
日付タイプ |
Created |
| 資源タイプ |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Article |
| その他の資源識別子 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
International Journal of Nanomedicine. 6(1):3487-3497 (2011) |
| 資源識別子URI |
|
|
識別子 |
http://hdl.handle.net/10091/13513 |
|
識別子タイプ |
HDL |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1176-9114 |
| 処理レコードID(総合目録DB) |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA1215861X |
| PubMed番号 |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed&term=22267932 |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
http://dx.doi.org/10.2147/IJN.S26689 |
| 権利 |
|
|
権利情報 |
Copyright © 2011 Haniu et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. |
| 権利 |
|
|
権利情報 |
CC BY-NC |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
https://soar-ir.repo.nii.ac.jp/?action=repository_action_common_download&item_id=362&item_no=1&attribute_id=65&file_no=1
