| Item type |
Journal Article(1) |
| 公開日 |
2021-03-01 |
| タイトル |
|
|
タイトル |
Effect of dispersants of multi-walled carbon nanotubes on cellular uptake and biological responses |
| 作成者(その他言語) |
Haniu, Hisao
Saito, Naoto
Matsuda, Yoshikazu
Kim, Yoong-Ahm
Park, Ki Chul
Tsukahara, Tamotsu
Usui, Yuki
Aoki, Kaoru
Shimizu, Masayuki
Ogihara, Nobuhide
Hara, Kazuo
Takanashi, Seiji
Okamoto, Masanori
Ishigaki, Norio
Nakamura, Koichi
Kato, Hiroyuki
|
| 公開者(その他言語) |
|
|
|
姓名 |
Dove, Medical Press |
| 書誌情報 |
International Journal of Nanomedicine
巻 1,
号 6,
p. 3295-3307,
発行日 2011-12-09
|
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
multi-walled carbon nanotube |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
cytotoxicity |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
intracellular concentration |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
dispersant |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
cytokine secretion |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
metadata only access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_14cb |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Although there have been many reports about the cytotoxicity of multi-walled carbon nanotubes (MWCNTs), the results are still controversial. To investigate one possible reason, the authors investigated the influence of MWCNT dispersants on cellular uptake and cytotoxicity. Cytotoxicity was examined (measured by alamarBlue® assay), as well as intracellular MWCNT concentration and cytokine secretion (measured by flow cytometry) in human bronchial epithelial cells (BEAS-2B) exposed to a type of highly purified MWCNT vapor grown carbon fiber (VGCF®, Showa Denko Kabushiki-gaisha, Tokyo, Japan) in three different dispersants (gelatin, carboxylmethyl cellulose, and 1,2-dipalmitoyl-sn-glycero-3-phosphocholine). The authors also researched the relationship between the intracellular concentration of MWCNTs and cytotoxicity by using two cell lines, BEAS-2B and MESO-1 human malignant pleural mesothelioma cells. The intracellular concentration of VGCF was different for each of the three dispersants, and the levels of cytotoxicity and inflammatory response were correlated with the intracellular concentration of VGCF. A relationship between the intracellular concentration of VGCF and cytotoxic effects was observed in both cell lines. The results indicate that dispersants affect VGCF uptake into cells and that cytotoxicity depends on the intracellular concentration of VGCF, not on the exposed dosage. Thus, toxicity appears to depend on exposure time, even at low VGCF concentrations, because VGCF is biopersistent. |
| 日付 |
|
|
日付 |
2015-09-18 |
|
日付タイプ |
Created |
| 資源タイプ |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Article |
| その他の資源識別子 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
International Journal of Nanomedicine. 6(1):3295-3307 (2011) |
| 資源識別子URI |
|
|
識別子 |
http://hdl.handle.net/10091/13514 |
|
識別子タイプ |
HDL |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1176-9114 |
| 処理レコードID(総合目録DB) |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA1215861X |
| PubMed番号 |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed&term=22228997 |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
http://dx.doi.org/10.2147/IJN.S26573 |
| 権利 |
|
|
権利情報 |
Copyright © 2011 Haniu et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. |
| 権利 |
|
|
権利情報 |
CC BY-NC |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
https://soar-ir.repo.nii.ac.jp/?action=repository_action_common_download&item_id=361&item_no=1&attribute_id=65&file_no=1
