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Preventive Effects of a Kampo Medicine, Hangeshashinto on Inflammatory Responses in ipopolysaccharide-Treated Human Gingival Fibroblasts
https://shinshu.repo.nii.ac.jp/records/22593
https://shinshu.repo.nii.ac.jp/records/2259347e466b3-6661-4792-9c5c-51299695e028
名前 / ファイル | ライセンス | アクション |
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https://mdu.repo.nii.ac.jp/?action=repository_action_common_download&item_id=2281&item_no=1&attribute_id=22&file_no=1
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Item type | Journal Article(1) | |||||
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公開日 | 2021-04-01 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Preventive Effects of a Kampo Medicine, Hangeshashinto on Inflammatory Responses in ipopolysaccharide-Treated Human Gingival Fibroblasts | |||||
その他(別言語等)のタイトル | ||||||
その他のタイトル | リポ多糖類処理を行ったヒト歯肉線維芽細胞の炎症反応に対する漢方薬半夏瀉心湯の予防効果 | |||||
作成者(その他言語) |
NAKAZONO, YODAI
× NAKAZONO, YODAI× ARA, TOSHIAKI× FUJINAMI, YOSHIAKI× HATTORI, TOSHIMI× WANG, PAO-LI |
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公開者(その他言語) | ||||||
姓名 | The, Hard Tissue Biology Network Association(JHTBNet) | |||||
書誌情報 |
Journal of Hard Tissue Biology 巻 19, 号 1, p. 43-50, 発行日 2010-03-10 |
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言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Anti-inflammatory effect | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Hangeshashinto | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Human gingival fibroblast | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Prostaglandin E2 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | In the present study, we investigated the effects of a Kampo medicine hangeshashinto (TJ-14) on the production of prostaglandin E2 (PGE2), interleukin (IL)-6 and IL-8 by human gingival fibroblasts (HGFs) treated with lipopolysaccharide (LPS) from Porphyromonas gingivalis. HGFs proliferation was dose-dependently decreased with hangeshashinto at days 3 and 7. However, treatment with LPS (10 ng/ml), hangeshashinto (up to 1 mg/ml) and their combinations for 24 h did not affect the viability of HGFs. Hangeshashinto dose-dependently suppressed LPS-induced PGE2 production but did not alter basal PGE2 level. Hangeshashinto weakly decreased LPS-induced IL-6 and IL-8 productions. Hangeshashinto decreased cyclooxygenase (COX)-1 and COX-2 activities to approximately 60% at 1 mg/ml. Hangeshashinto decreased cytoplasmic phospholipase A2 (cPLA2) expression and LPS-induced COX-2 expression but not affected annexin1 expression. Hangeshashinto weakly suppressed LPS-induced extracellular signal-regulated kinase (ERK) phosphorylation, which is known to lead to ERK activation and cPLA2 phosphorylation. These results suggest that hangeshashinto decreased PGE2 production by (1) suppression of cPLA2 and LPS-induced COX-2 expression, and to a lesser extent, (2) inhibition of COX-2 activity and (3) inhibition of cPLA2 phosphorylation and its activation via inhibition of ERK phosphorylation. Moreover, it is also suggested that hangeshashinto may be useful to improve gingival inflammation in periodontal disease. | |||||
日付 | ||||||
日付 | 2014-10-07 | |||||
日付タイプ | Created | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
資源識別子URI | ||||||
識別子 | http://id.nii.ac.jp/1070/00002275/ | |||||
識別子タイプ | URI | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1880-828x | |||||
処理レコードID(総合目録DB) | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11074332 | |||||
情報源 | ||||||
関連名称 | http://doi.org/10.2485/jhtb.19.43 | |||||
他の資源との関係 | ||||||
関連名称 | 2010年度 松本歯科大学大学院歯学独立研究科 博士学位論文(歯学):33602乙第17号 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.2485/jhtb.19.43 | |||||
NII論文ID | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | NAID | |||||
関連識別子 | http://ci.nii.ac.jp/naid/10030688335 | |||||
医中誌ID | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | ICHUSHI | |||||
関連識別子 | https://search.jamas.or.jp/link/ui/2011052693 | |||||
権利 | ||||||
権利情報 | Copyright © 2010 by The Hard Tissue Biology Network Association(JHTBNet) | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |