Concise synthesis of legioliulin, an isocoumarin compound isolated from Legionella dumoffii, was achieved. Isocoumarin ring of legioliulin was constructed using cyclic acylpalladation. Chain elongation was performed using Heck reaction using t-butylphosphine as a ligand. (C) 2016 Elsevier Ltd. All rights reserved.
Synthesis of legioliulin, a fluorescent isocoumarin compound, isolated from Legionella dumoffii using cyclic acylpalladation and Heck reaction
