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  1. 松本歯科大学
  2. 学術雑誌論文
  3. International Journal of Medical Sciences
  1. 松本歯科大学
  2. 成果物登録者(学内著者)一覧
  3. K
  4. Toshiyuki Kawakami
  1. 松本歯科大学
  2. 成果物登録者(学内著者)一覧
  3. H
  4. Hiromasa Hasegawa
  1. 松本歯科大学
  2. 成果物登録者(学内著者)一覧
  3. N
  4. Keisuke Nakano
  1. 松本歯科大学
  2. 成果物登録者(学内著者)一覧
  3. O
  4. Takanaga Ochiai
  1. 松本歯科大学
  2. 成果物登録者(学内著者)一覧
  3. O
  4. Naoto Osuga
  1. 松本歯科大学
  2. 成果物登録者(学内著者)一覧
  3. O
  4. Norimasa Okafuji
  1. 松本歯科大学
  2. 成果物登録者(学内著者)一覧
  3. M
  4. Saeka Matsuda
  1. 松本歯科大学
  2. 成果物登録者(学内著者)一覧
  3. S
  4. Masahito Shoumura

Migration and Differentiation of GFP-transplanted Bone Marrow-derived Cells into Experimentally Induced Periodontal Polyp in Mice.

https://shinshu.repo.nii.ac.jp/records/42666
https://shinshu.repo.nii.ac.jp/records/42666
9f4976d2-06ac-48d1-b008-8a107f205ad2
名前 / ファイル ライセンス アクション
/ https://mdu.repo.nii.ac.jp/?action=repository_action_common_download&item_id=2686&item_no=1&attribute_id=22&file_no=1
Item type Journal Article(1)
公開日 2021-04-01
タイトル
タイトル Migration and Differentiation of GFP-transplanted Bone Marrow-derived Cells into Experimentally Induced Periodontal Polyp in Mice.
言語 en
作成者(その他言語) MATSUDA, SAEKA

× MATSUDA, SAEKA

MATSUDA, SAEKA
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SHOUMURA, MASAHITO

× SHOUMURA, MASAHITO

SHOUMURA, MASAHITO
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OSUGA, NAOTO

× OSUGA, NAOTO

OSUGA, NAOTO
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TSUJIGIWA, HIDETSUGU

× TSUJIGIWA, HIDETSUGU

TSUJIGIWA, HIDETSUGU
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NAKANO, KEISUKE

× NAKANO, KEISUKE

NAKANO, KEISUKE
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OKAFUJI, NORIMASA

× OKAFUJI, NORIMASA

OKAFUJI, NORIMASA
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OCHIAI, TAKANAGA

× OCHIAI, TAKANAGA

OCHIAI, TAKANAGA
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HASEGAWA, HIROMASA

× HASEGAWA, HIROMASA

HASEGAWA, HIROMASA
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KAWAKAMI, TOSHIYUKI

× KAWAKAMI, TOSHIYUKI

KAWAKAMI, TOSHIYUKI
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公開者(その他言語)
姓名 Ivyspring, International Publisher
書誌情報 International Journal of Medical Science

巻 13, 号 7, p. 500-506, 発行日 2016-06-29
言語
言語 eng
キーワード
主題Scheme Other
主題 Periodontal polyp
キーワード
主題Scheme Other
主題 Periodontal ligament
キーワード
主題Scheme Other
主題 Cell differentiation
キーワード
主題Scheme Other
主題 Immunohistochemistry
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
内容記述
内容記述タイプ Other
内容記述 Perforation of floor of the dental pulp is often encountered during root canal treatment in routine clinical practice of dental caries. If perforation were large, granulation tissue would grow to form periodontal polyp. Granulation tissue consists of proliferating cells however their origin is not clear. It was shown that the cells in granulation tissue are mainly from migration of undifferentiated mesenchymal cells of the bone marrow. Hence, this study utilized GFP bone marrow transplantation mouse model. The floor of the pulp chamber in maxillary first molar was perforated using ½ dental round bur. Morphological assessment was carried out by micro CT and microscopy and GFP cell mechanism was further assessed by immunohistochemistry using double fluorescent staining with GFP-S100A4; GFP-Runx2 and GFP-CD31. Results of micro CT revealed alveolar bone resorption and widening of periodontal ligament. Histopathological examination showed proliferation of fibroblasts with some round cells and blood vessels in the granulation tissue. At 2 weeks, the outermost layer of the granulation tissue was lined by squamous cells with distinct intercellular bridges. At 4 weeks, the granulation tissue became larger than the perforation and the outermost layer was lined by relatively typical stratified squamous epithelium. Double immunofluorescent staining of GFP and Runx2 revealed that both proteins were expressed in spindle-shaped cells. Double immunofluorescent staining of GFP and CD31 revealed that both proteins were expressed in vascular endothelial cells in morphologically distinct vessels. The results suggest that fibroblasts, periodontal ligament fibroblasts and blood vessels in granulation tissue were derived from transplanted-bone marrow cells. Thus, essential growth of granulation tissue in periodontal polyp was caused by the migration of undifferentiated mesenchymal cells derived from bone marrow, which differentiated into fibroblasts and later on differentiated into other cells in response to injury.
日付
日付 2018-03-01
日付タイプ Created
フォーマット
内容記述タイプ Other
内容記述 application/pdf
資源識別子URI
識別子 http://id.nii.ac.jp/1070/00002678/
識別子タイプ URI
ISSN
収録物識別子タイプ ISSN
収録物識別子 1449-1907
情報源
関連名称 雑誌掲載論文(電子版)
情報源
関連名称 http://www.medsci.org/v13p0500.htm
情報源
関連名称 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946120/
PubMed番号
関連タイプ isIdenticalTo
識別子タイプ PMID
関連識別子 info:pmid/27429586
DOI
関連タイプ isIdenticalTo
識別子タイプ DOI
関連識別子 https://doi.org/10.7150/ijms.15671
権利
権利情報 © Ivyspring International Publisher. This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See http://ivyspring.com/terms for full terms and conditions.
権利
権利情報 CC BY
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
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