The effect of a prostaglandin E-1 derivative on the symptoms and quality of life of patients with lumbar spinal stenosis

Takahashi, Jun; Kobayashi, Hirokazu; Wakabayashi, Shinji; Deguchi, Masao; Ito, Hidehiro; Mogami, Yuji; Tanikawa, Hirotaka; Nakagawa, Hiroyuki; Moriya, Hideki; Ashizawa, Ryohei; Takahara, Kenji; Kinoshita, Hisatoshi; Tateiwa, Yutaka; Misawa, Hiromichi; Tsutsumimoto, Takahiro; Nakakohji, Taku; Yuzawa, Yohei; Sawaumi, Akihito; Hidai, Yohei; Matsuda, Satoshi; Nakamura, Isao; Toba, Shigeyuki; Kamimura, Mikio; Nakane, Takeshi; Hirabayashi, Hiroki; Hashidate, Hiroyuki; Ogihara, Nobuhide; Mukaiyama, Keijiro; Kato, Hiroyuki; Ohtsuka, Kuniyoshi

doi:http://dx.doi.org/10.1007/s00776-012-0342-5

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The effect of a prostaglandin E-1 derivative on the symptoms and quality of life of patients with lumbar spinal stenosis

https://shinshu.repo.nii.ac.jp/records/31353

名前 / ファイル	ライセンス	アクション
https://soar-ir.repo.nii.ac.jp/?action=repository_action_common_download&item_id=8007&item_no=1&attribute_id=65&file_no=1

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Journal Article(1)

公開日

2020-09-02

タイトル

The effect of a prostaglandin E-1 derivative on the symptoms and quality of life of patients with lumbar spinal stenosis

作成者(その他言語)

Takahashi, Jun
Kobayashi, Hirokazu
Wakabayashi, Shinji
Deguchi, Masao
Ito, Hidehiro
Mogami, Yuji
Tanikawa, Hirotaka
Nakagawa, Hiroyuki
Moriya, Hideki
Ashizawa, Ryohei
Takahara, Kenji
Kinoshita, Hisatoshi
Tateiwa, Yutaka
Misawa, Hiromichi
Tsutsumimoto, Takahiro
Nakakohji, Taku
Yuzawa, Yohei
Sawaumi, Akihito
Hidai, Yohei
Matsuda, Satoshi
Nakamura, Isao
Toba, Shigeyuki
Kamimura, Mikio
Nakane, Takeshi
Hirabayashi, Hiroki
Hashidate, Hiroyuki
Ogihara, Nobuhide
Mukaiyama, Keijiro
Kato, Hiroyuki
Ohtsuka, Kuniyoshi

公開者(その他言語)

姓名

SPRINGER, JAPAN KK

書誌情報

JOURNAL OF ORTHOPAEDIC SCIENCE

巻 18, 号 2, p. 208-215, 発行日 2013-03

言語

eng

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http://purl.org/coar/resource_type/c_6501

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journal article

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metadata only access

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http://purl.org/coar/access_right/c_14cb

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Other

内容記述

Quality of life (QOL) is a concern for patients with lumbar spinal stenosis (LSS). In this study, QOL was examined using the 5-item EuroQol (EQ-5D). QOL and activities of daily living (ADL) were surveyed for 91 patients who visited 18 medical institutions in our prefecture and were diagnosed with LSS-associated intermittent claudication. A second survey was performed after a parts per thousand yen6 weeks for 79 of the subjects to evaluate therapy with limaprost (an oral prostaglandin E1 derivative) or etodolac (an NSAID). Symptoms, maximum walking time, QOL, ADL items, and relationships among these variables were investigated for all 91 patients. Leg pain, leg numbness, and low back pain while walking were surveyed by use of VAS scores (0-100). Leg pain, leg numbness, and low back pain while walking (VAS a parts per thousand yen25) were present in 83.5, 62.6, and 54.9 % of the patients in the first survey, and approximately half of the patients had a maximum walking time < 15 min. The mean EQ-5D utility value for QOL was 0.59 +/- A 0.12. This value was significantly associated with maximum walking time (p = 0.030) based on classification of patients into groups with walking times < 7.5, 7.5-15, 15-30, and > 30 min, showing that maximum walking time affected health-related QOL. Of the 79 patients who completed the second survey, 56 had taken limaprost and 23 (control group) had received etodolac. Limaprost improved possible walking time, reduced ADL interference, and significantly increased the EQ-5D utility score, whereas no significant changes occurred in the control group. Maximum walking time was prolonged by a parts per thousand yen10 min and the EQ-5D utility value was improved by a parts per thousand yen0.1 points in significantly more patients in the limaprost group than in the control group. According to the findings of this survey, at an average of 8 weeks after administration limaprost improved symptoms, QOL, and ADL in LSS patients whereas treatment with an NSAID reduced pain but did not have any other effects.

日付

2015-09-25

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Created

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Article

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内容記述

JOURNAL OF ORTHOPAEDIC SCIENCE. 18(2):208-215 (2013)

資源識別子URI

識別子

http://hdl.handle.net/10091/17834

識別子タイプ

HDL

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収録物識別子タイプ

ISSN

収録物識別子

0949-2658

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収録物識別子タイプ

NCID

収録物識別子

AA11052566

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2023-05-15 21:05:43.697776

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The effect of a prostaglandin E-1 derivative on the symptoms and quality of life of patients with lumbar spinal stenosis

× Takahashi, Jun

× Kobayashi, Hirokazu

× Wakabayashi, Shinji

× Deguchi, Masao

× Ito, Hidehiro

× Mogami, Yuji

× Tanikawa, Hirotaka

× Nakagawa, Hiroyuki

× Moriya, Hideki

× Ashizawa, Ryohei

× Takahara, Kenji

× Kinoshita, Hisatoshi

× Tateiwa, Yutaka

× Misawa, Hiromichi

× Tsutsumimoto, Takahiro

× Nakakohji, Taku

× Yuzawa, Yohei

× Sawaumi, Akihito

× Hidai, Yohei

× Matsuda, Satoshi

× Nakamura, Isao

× Toba, Shigeyuki

× Kamimura, Mikio

× Nakane, Takeshi

× Hirabayashi, Hiroki

× Hashidate, Hiroyuki

× Ogihara, Nobuhide

× Mukaiyama, Keijiro

× Kato, Hiroyuki

× Ohtsuka, Kuniyoshi

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