We report a case of neurilemmoma of the trigonum caroticum occurring in a 34-year-old female. She was referred to our clinic by a general practitioner because of a painless swelling in the right side of the submandibular region persisting for the previous 10 years. The mass in the submandibular region appeared to be unattached to the skin and freely movable. There were no palpable submandibular lymph nodes. This lesion was clinically diagnosed as a benign tumor of the submandibular gland. The removed mass, measuring 50×30×30mm, was encapsulated by a thin fibrous membrane. Histopathologically it was diagnosed as neurilemmoma (Antoni of type A and B). No recurrences have been noted for two years after the surgical procedure. Discussion mainly focuses on the differential diagnosis between neurilemmoma and other lesions of the trigonum caroticum.