Previously, we reported that BMP-induced heterotopic osteogenesis was thought to belong the third ossification mode, as described by Yasui et al. We reported that transchondroid bone formation and that BMP-induced heterotopic bone was "chondroid bone," a tissue intermediate between cartilage and bone, by histochemical examinations. Therefore, we have investigated the characteristics of BMP-induced heterotopic transchondroid bone formation using histochemical and immunohistochemical techniques, especially the localization of typical matrix proteins of cartilage and bone: collagen type I and type II antibodies. We found that both collagen peptides were detected in the matrix of "chondroid bone" in the early phase of BMP-induced heterotopic transchondroid bone formation. Therefore, we believe that the third ossification mode, "transchondriod bone formation", was chiefly displayed in the BMP-induced heterotopic osteogenesis.
骨形成因子により誘導される類軟骨性骨化の病理学的検討
