The aim of this study was the histopathological evaluation of the subcutaneous tissue reaction to a newly developed root canal filling material (HP paste). We injected HP paste and a control paste using a calcium hydroxide/water mixed paste as a control subcutaneously into the dorsal area of 6-week-old anesthetized male ddY mice. Two days, 1 week, 3 and 12 weeks after injection, the tissue surrounding the injection sites was removed from mice in each group and examined. We found necrotic and degeneration changes due to the pastes, as well as foreign body reactions or granulation tissue proliferation in each group, until 3 weeks after injection. No inflammatory cell infiltration was observed in the experimental group, although there was some in the control group in the 12-week specimens. In conclusion, our data leads us to believe the HP paste is safely usable as a root canal filling material.
試作水酸化カルシウム系糊剤根管充填材に対する組織反応
