The aim of this study was to evaluate the utility of liquid-based cytology (LBC) for diagnosis of oral mucosal lesions, compared with the conventional smear cytology. Specimens were taken from the same patient by the both conventional and LBC preparation methods. Samples were stained with papanicolaou and PAS stainings according to standard methods. RNA and protein were isolated from LBC samples. The cytological features of LBC samples showed similar quality to those of conventional ones. In addition, RNA and protein could be detected from LBC samples. In conclusion, LBC specimens are useful not only for cytological diagnosis but also for gene and protein analyses in oral lesions.
口腔粘膜病変における液状化細胞診の検討
